Effect of adriamycin on CFUGM at plasma concentrations found following therapeutic infusions.

The effect of adriamycin on human and mouse CFUGM was examined at concentrations and times suggested by plasma clearance data derived from the results of a number of published studies. Our results suggest that the high concentrations of drug present in the plasma for short periods of time following...

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Autores principales: Bailey-Wood, R., Dallimore, C. M., Whittaker, J. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976788/
https://www.ncbi.nlm.nih.gov/pubmed/6466545
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author Bailey-Wood, R.
Dallimore, C. M.
Whittaker, J. A.
author_facet Bailey-Wood, R.
Dallimore, C. M.
Whittaker, J. A.
author_sort Bailey-Wood, R.
collection PubMed
description The effect of adriamycin on human and mouse CFUGM was examined at concentrations and times suggested by plasma clearance data derived from the results of a number of published studies. Our results suggest that the high concentrations of drug present in the plasma for short periods of time following infusion are only weakly cytotoxic towards the CFUGM when incubated for similar times. In contrast, there was a considerably greater cytotoxic effect when the drug was examined at low concentrations for periods similar to those described for the terminal phase of adriamycin clearance. The principal metabolite, adriamycinol, was poorly cytotoxic.
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spelling pubmed-19767882009-09-10 Effect of adriamycin on CFUGM at plasma concentrations found following therapeutic infusions. Bailey-Wood, R. Dallimore, C. M. Whittaker, J. A. Br J Cancer Research Article The effect of adriamycin on human and mouse CFUGM was examined at concentrations and times suggested by plasma clearance data derived from the results of a number of published studies. Our results suggest that the high concentrations of drug present in the plasma for short periods of time following infusion are only weakly cytotoxic towards the CFUGM when incubated for similar times. In contrast, there was a considerably greater cytotoxic effect when the drug was examined at low concentrations for periods similar to those described for the terminal phase of adriamycin clearance. The principal metabolite, adriamycinol, was poorly cytotoxic. Nature Publishing Group 1984-09 /pmc/articles/PMC1976788/ /pubmed/6466545 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Bailey-Wood, R.
Dallimore, C. M.
Whittaker, J. A.
Effect of adriamycin on CFUGM at plasma concentrations found following therapeutic infusions.
title Effect of adriamycin on CFUGM at plasma concentrations found following therapeutic infusions.
title_full Effect of adriamycin on CFUGM at plasma concentrations found following therapeutic infusions.
title_fullStr Effect of adriamycin on CFUGM at plasma concentrations found following therapeutic infusions.
title_full_unstemmed Effect of adriamycin on CFUGM at plasma concentrations found following therapeutic infusions.
title_short Effect of adriamycin on CFUGM at plasma concentrations found following therapeutic infusions.
title_sort effect of adriamycin on cfugm at plasma concentrations found following therapeutic infusions.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976788/
https://www.ncbi.nlm.nih.gov/pubmed/6466545
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