An evaluation of high-dose medroxyprogesterone acetate (MPA) therapy in women with advanced breast cancer.

The efficacy of high-dose intramuscular MPA therapy in controlling progressive measurable metastatic breast carcinoma was assessed in 32 women. In addition serial measurements of MPA blood levels were carried out in 20 of the patients and subjective effects of treatment were monitored in detail in 1...

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Autores principales: Johnson, J. R., Priestman, T. J., Fotherby, K., Kelly, K. A., Priestman, S. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976793/
https://www.ncbi.nlm.nih.gov/pubmed/6235831
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author Johnson, J. R.
Priestman, T. J.
Fotherby, K.
Kelly, K. A.
Priestman, S. G.
author_facet Johnson, J. R.
Priestman, T. J.
Fotherby, K.
Kelly, K. A.
Priestman, S. G.
author_sort Johnson, J. R.
collection PubMed
description The efficacy of high-dose intramuscular MPA therapy in controlling progressive measurable metastatic breast carcinoma was assessed in 32 women. In addition serial measurements of MPA blood levels were carried out in 20 of the patients and subjective effects of treatment were monitored in detail in 18 of the women. Overall 6 patients (19%) gained an objective response and a further 7 (22%) experienced disease stasis from 4-17 months whilst on treatment. Significant differences in serum MPA levels were seen between responders and non-responders, objective tumour shrinkage only being seen in those patients who rapidly attained, and sustained, blood levels in excess of 100 ng ml-1. Subjective assessment showed no evidence of a euphoriant effect of MPA therapy in the non-responders group.
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spelling pubmed-19767932009-09-10 An evaluation of high-dose medroxyprogesterone acetate (MPA) therapy in women with advanced breast cancer. Johnson, J. R. Priestman, T. J. Fotherby, K. Kelly, K. A. Priestman, S. G. Br J Cancer Research Article The efficacy of high-dose intramuscular MPA therapy in controlling progressive measurable metastatic breast carcinoma was assessed in 32 women. In addition serial measurements of MPA blood levels were carried out in 20 of the patients and subjective effects of treatment were monitored in detail in 18 of the women. Overall 6 patients (19%) gained an objective response and a further 7 (22%) experienced disease stasis from 4-17 months whilst on treatment. Significant differences in serum MPA levels were seen between responders and non-responders, objective tumour shrinkage only being seen in those patients who rapidly attained, and sustained, blood levels in excess of 100 ng ml-1. Subjective assessment showed no evidence of a euphoriant effect of MPA therapy in the non-responders group. Nature Publishing Group 1984-09 /pmc/articles/PMC1976793/ /pubmed/6235831 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Johnson, J. R.
Priestman, T. J.
Fotherby, K.
Kelly, K. A.
Priestman, S. G.
An evaluation of high-dose medroxyprogesterone acetate (MPA) therapy in women with advanced breast cancer.
title An evaluation of high-dose medroxyprogesterone acetate (MPA) therapy in women with advanced breast cancer.
title_full An evaluation of high-dose medroxyprogesterone acetate (MPA) therapy in women with advanced breast cancer.
title_fullStr An evaluation of high-dose medroxyprogesterone acetate (MPA) therapy in women with advanced breast cancer.
title_full_unstemmed An evaluation of high-dose medroxyprogesterone acetate (MPA) therapy in women with advanced breast cancer.
title_short An evaluation of high-dose medroxyprogesterone acetate (MPA) therapy in women with advanced breast cancer.
title_sort evaluation of high-dose medroxyprogesterone acetate (mpa) therapy in women with advanced breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976793/
https://www.ncbi.nlm.nih.gov/pubmed/6235831
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