Cargando…

The cytostatic activity of cultured Kupffer cells.

The cytostatic activity of a population of cultured syngeneic and allogeneic Kupffer cells against the K31 tumour cell line has been studied in vitro. The addition of purified populations if Kupffer cells to the tumour cell line resulted in a reduction in the uptake of 125IUdR by the tumour cells. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Pulford, K., Souhami, R. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976816/
https://www.ncbi.nlm.nih.gov/pubmed/3966971
_version_ 1782135133343580160
author Pulford, K.
Souhami, R. L.
author_facet Pulford, K.
Souhami, R. L.
author_sort Pulford, K.
collection PubMed
description The cytostatic activity of a population of cultured syngeneic and allogeneic Kupffer cells against the K31 tumour cell line has been studied in vitro. The addition of purified populations if Kupffer cells to the tumour cell line resulted in a reduction in the uptake of 125IUdR by the tumour cells. This cytostatic activity was not due to a non-labile supernatant effect. There was a progressive loss of the cytostatic activity of the Kupffer cells as their time in culture increased. The experiments show that Kupffer cells, like other macrophages, possess cytostatic activity in vitro which is not genetically restricted.
format Text
id pubmed-1976816
institution National Center for Biotechnology Information
language English
publishDate 1985
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19768162009-09-10 The cytostatic activity of cultured Kupffer cells. Pulford, K. Souhami, R. L. Br J Cancer Research Article The cytostatic activity of a population of cultured syngeneic and allogeneic Kupffer cells against the K31 tumour cell line has been studied in vitro. The addition of purified populations if Kupffer cells to the tumour cell line resulted in a reduction in the uptake of 125IUdR by the tumour cells. This cytostatic activity was not due to a non-labile supernatant effect. There was a progressive loss of the cytostatic activity of the Kupffer cells as their time in culture increased. The experiments show that Kupffer cells, like other macrophages, possess cytostatic activity in vitro which is not genetically restricted. Nature Publishing Group 1985-01 /pmc/articles/PMC1976816/ /pubmed/3966971 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Pulford, K.
Souhami, R. L.
The cytostatic activity of cultured Kupffer cells.
title The cytostatic activity of cultured Kupffer cells.
title_full The cytostatic activity of cultured Kupffer cells.
title_fullStr The cytostatic activity of cultured Kupffer cells.
title_full_unstemmed The cytostatic activity of cultured Kupffer cells.
title_short The cytostatic activity of cultured Kupffer cells.
title_sort cytostatic activity of cultured kupffer cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976816/
https://www.ncbi.nlm.nih.gov/pubmed/3966971
work_keys_str_mv AT pulfordk thecytostaticactivityofculturedkupffercells
AT souhamirl thecytostaticactivityofculturedkupffercells
AT pulfordk cytostaticactivityofculturedkupffercells
AT souhamirl cytostaticactivityofculturedkupffercells