Effects of the induction of hepatic microsomal metabolism on the toxicity of cyclophosphamide.

Cyclophosphamide (CP) administration to rats in a single i.p. dose (200 mg kg-1), while producing urinary bladder toxicity and 30-40% depression of the hepatic microsomal mixed function oxidase (MFO), failed to produce any depression of MFO activities in extrahepatic tissues such as lung, kidney and...

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Detalles Bibliográficos
Autores principales: Gurtoo, H. L., Bansal, S. K., Pavelic, Z., Struck, R. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976820/
https://www.ncbi.nlm.nih.gov/pubmed/3966972
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author Gurtoo, H. L.
Bansal, S. K.
Pavelic, Z.
Struck, R. F.
author_facet Gurtoo, H. L.
Bansal, S. K.
Pavelic, Z.
Struck, R. F.
author_sort Gurtoo, H. L.
collection PubMed
description Cyclophosphamide (CP) administration to rats in a single i.p. dose (200 mg kg-1), while producing urinary bladder toxicity and 30-40% depression of the hepatic microsomal mixed function oxidase (MFO), failed to produce any depression of MFO activities in extrahepatic tissues such as lung, kidney and intestine. Phenobarbital pretreatment of the rats, which is known to enhance hepatic microsomal activation of CP, protected against CP-induced urinary bladder toxicity and the depression of hepatic MFO activities. This protection appears to be, at least in part, related to phenobarbital induction of hepatic cytochrome P-450 isozyme(s) that metabolizes CP to a new metabolite tentatively identified as didechlorodihydroxycyclophosphamide.
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spelling pubmed-19768202009-09-10 Effects of the induction of hepatic microsomal metabolism on the toxicity of cyclophosphamide. Gurtoo, H. L. Bansal, S. K. Pavelic, Z. Struck, R. F. Br J Cancer Research Article Cyclophosphamide (CP) administration to rats in a single i.p. dose (200 mg kg-1), while producing urinary bladder toxicity and 30-40% depression of the hepatic microsomal mixed function oxidase (MFO), failed to produce any depression of MFO activities in extrahepatic tissues such as lung, kidney and intestine. Phenobarbital pretreatment of the rats, which is known to enhance hepatic microsomal activation of CP, protected against CP-induced urinary bladder toxicity and the depression of hepatic MFO activities. This protection appears to be, at least in part, related to phenobarbital induction of hepatic cytochrome P-450 isozyme(s) that metabolizes CP to a new metabolite tentatively identified as didechlorodihydroxycyclophosphamide. Nature Publishing Group 1985-01 /pmc/articles/PMC1976820/ /pubmed/3966972 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Gurtoo, H. L.
Bansal, S. K.
Pavelic, Z.
Struck, R. F.
Effects of the induction of hepatic microsomal metabolism on the toxicity of cyclophosphamide.
title Effects of the induction of hepatic microsomal metabolism on the toxicity of cyclophosphamide.
title_full Effects of the induction of hepatic microsomal metabolism on the toxicity of cyclophosphamide.
title_fullStr Effects of the induction of hepatic microsomal metabolism on the toxicity of cyclophosphamide.
title_full_unstemmed Effects of the induction of hepatic microsomal metabolism on the toxicity of cyclophosphamide.
title_short Effects of the induction of hepatic microsomal metabolism on the toxicity of cyclophosphamide.
title_sort effects of the induction of hepatic microsomal metabolism on the toxicity of cyclophosphamide.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976820/
https://www.ncbi.nlm.nih.gov/pubmed/3966972
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AT struckrf effectsoftheinductionofhepaticmicrosomalmetabolismonthetoxicityofcyclophosphamide

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