Breast cancer: relationship between the size of the primary tumour and the probability of metastatic dissemination.

The relationship between the size of the primary tumour upon initial treatment and the incidence of distant metastasis during the course of the disease was investigated using data from 2648 breast cancers treated at the Institut Gustave Roussy between 1954 and 1972. This analysis suggests the existe...

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Autores principales: Koscielny, S., Tubiana, M., Lê, M. G., Valleron, A. J., Mouriesse, H., Contesso, G., Sarrazin, D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976833/
https://www.ncbi.nlm.nih.gov/pubmed/6733019
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author Koscielny, S.
Tubiana, M.
Lê, M. G.
Valleron, A. J.
Mouriesse, H.
Contesso, G.
Sarrazin, D.
author_facet Koscielny, S.
Tubiana, M.
Lê, M. G.
Valleron, A. J.
Mouriesse, H.
Contesso, G.
Sarrazin, D.
author_sort Koscielny, S.
collection PubMed
description The relationship between the size of the primary tumour upon initial treatment and the incidence of distant metastasis during the course of the disease was investigated using data from 2648 breast cancers treated at the Institut Gustave Roussy between 1954 and 1972. This analysis suggests the existence for each tumour of a critical volume (threshold) at which the first remote metastasis is initiated. The correlation between the size of the primary tumour and the probability of metastatic dissemination was assessed as well as the influence on this correlation of two prognostic indicators: histological grade and number of involved lymph nodes. It was found that the threshold volume is strongly correlated with the number of involved lymph nodes and the histological grading.
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spelling pubmed-19768332009-09-10 Breast cancer: relationship between the size of the primary tumour and the probability of metastatic dissemination. Koscielny, S. Tubiana, M. Lê, M. G. Valleron, A. J. Mouriesse, H. Contesso, G. Sarrazin, D. Br J Cancer Research Article The relationship between the size of the primary tumour upon initial treatment and the incidence of distant metastasis during the course of the disease was investigated using data from 2648 breast cancers treated at the Institut Gustave Roussy between 1954 and 1972. This analysis suggests the existence for each tumour of a critical volume (threshold) at which the first remote metastasis is initiated. The correlation between the size of the primary tumour and the probability of metastatic dissemination was assessed as well as the influence on this correlation of two prognostic indicators: histological grade and number of involved lymph nodes. It was found that the threshold volume is strongly correlated with the number of involved lymph nodes and the histological grading. Nature Publishing Group 1984-06 /pmc/articles/PMC1976833/ /pubmed/6733019 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Koscielny, S.
Tubiana, M.
Lê, M. G.
Valleron, A. J.
Mouriesse, H.
Contesso, G.
Sarrazin, D.
Breast cancer: relationship between the size of the primary tumour and the probability of metastatic dissemination.
title Breast cancer: relationship between the size of the primary tumour and the probability of metastatic dissemination.
title_full Breast cancer: relationship between the size of the primary tumour and the probability of metastatic dissemination.
title_fullStr Breast cancer: relationship between the size of the primary tumour and the probability of metastatic dissemination.
title_full_unstemmed Breast cancer: relationship between the size of the primary tumour and the probability of metastatic dissemination.
title_short Breast cancer: relationship between the size of the primary tumour and the probability of metastatic dissemination.
title_sort breast cancer: relationship between the size of the primary tumour and the probability of metastatic dissemination.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976833/
https://www.ncbi.nlm.nih.gov/pubmed/6733019
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