Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum.

Study of expression of ras-related oncogenes in human premalignant polyps and malignant tumours of the colorectum, as well as in normal colorectal mucosa, shows a significant elevation in the premalignant and malignant tissues as compared to their respective colorectal mucosa. These results suggest...

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Detalles Bibliográficos
Autores principales: Spandidos, D. A., Kerr, I. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976851/
https://www.ncbi.nlm.nih.gov/pubmed/6733017
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author Spandidos, D. A.
Kerr, I. B.
author_facet Spandidos, D. A.
Kerr, I. B.
author_sort Spandidos, D. A.
collection PubMed
description Study of expression of ras-related oncogenes in human premalignant polyps and malignant tumours of the colorectum, as well as in normal colorectal mucosa, shows a significant elevation in the premalignant and malignant tissues as compared to their respective colorectal mucosa. These results suggest that activation of the ras oncogene family occurs in the development of colorectal tumours and that elevated expression at a premalignant stage may well be critical in the process of carcinogenesis but not in itself sufficient. IMAGES:
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spelling pubmed-19768512009-09-10 Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum. Spandidos, D. A. Kerr, I. B. Br J Cancer Research Article Study of expression of ras-related oncogenes in human premalignant polyps and malignant tumours of the colorectum, as well as in normal colorectal mucosa, shows a significant elevation in the premalignant and malignant tissues as compared to their respective colorectal mucosa. These results suggest that activation of the ras oncogene family occurs in the development of colorectal tumours and that elevated expression at a premalignant stage may well be critical in the process of carcinogenesis but not in itself sufficient. IMAGES: Nature Publishing Group 1984-06 /pmc/articles/PMC1976851/ /pubmed/6733017 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Spandidos, D. A.
Kerr, I. B.
Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum.
title Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum.
title_full Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum.
title_fullStr Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum.
title_full_unstemmed Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum.
title_short Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum.
title_sort elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976851/
https://www.ncbi.nlm.nih.gov/pubmed/6733017
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AT kerrib elevatedexpressionofthehumanrasoncogenefamilyinpremalignantandmalignanttumoursofthecolorectum

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