The effects of glutathione depletion on thermotolerance and heat stress protein synthesis.

The effects of cellular glutathione depletion by buthionine sulfoximine on the development of thermotolerance and synthesis of heat stress protein was studied. Cellular glutathione levels were found to increase rapidly following an acute heat treatment of either 12 min at 45.5 degrees C or 1 h at 43...

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Autores principales: Russo, A., Mitchell, J. B., McPherson, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976852/
https://www.ncbi.nlm.nih.gov/pubmed/6733022
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author Russo, A.
Mitchell, J. B.
McPherson, S.
author_facet Russo, A.
Mitchell, J. B.
McPherson, S.
author_sort Russo, A.
collection PubMed
description The effects of cellular glutathione depletion by buthionine sulfoximine on the development of thermotolerance and synthesis of heat stress protein was studied. Cellular glutathione levels were found to increase rapidly following an acute heat treatment of either 12 min at 45.5 degrees C or 1 h at 43 degrees C and remain elevated for prolonged periods. Glutathione depletion and prevention of glutathione synthesis by buthionine sulfoximine resulted in inhibition of the development of thermotolerance and a decrease in total protein as well as specific heat stress proteins. While the degree of inhibition of thermotolerance was similar for both glutathione depletion protocols, inhibition in heat stress protein synthesis was greater when glutathione was depleted to low levels prior to heating. The possible role of glutathione and the cellular redox state to thermotolerance and synthesis of heat stress protein is discussed. IMAGES:
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spelling pubmed-19768522009-09-10 The effects of glutathione depletion on thermotolerance and heat stress protein synthesis. Russo, A. Mitchell, J. B. McPherson, S. Br J Cancer Research Article The effects of cellular glutathione depletion by buthionine sulfoximine on the development of thermotolerance and synthesis of heat stress protein was studied. Cellular glutathione levels were found to increase rapidly following an acute heat treatment of either 12 min at 45.5 degrees C or 1 h at 43 degrees C and remain elevated for prolonged periods. Glutathione depletion and prevention of glutathione synthesis by buthionine sulfoximine resulted in inhibition of the development of thermotolerance and a decrease in total protein as well as specific heat stress proteins. While the degree of inhibition of thermotolerance was similar for both glutathione depletion protocols, inhibition in heat stress protein synthesis was greater when glutathione was depleted to low levels prior to heating. The possible role of glutathione and the cellular redox state to thermotolerance and synthesis of heat stress protein is discussed. IMAGES: Nature Publishing Group 1984-06 /pmc/articles/PMC1976852/ /pubmed/6733022 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Russo, A.
Mitchell, J. B.
McPherson, S.
The effects of glutathione depletion on thermotolerance and heat stress protein synthesis.
title The effects of glutathione depletion on thermotolerance and heat stress protein synthesis.
title_full The effects of glutathione depletion on thermotolerance and heat stress protein synthesis.
title_fullStr The effects of glutathione depletion on thermotolerance and heat stress protein synthesis.
title_full_unstemmed The effects of glutathione depletion on thermotolerance and heat stress protein synthesis.
title_short The effects of glutathione depletion on thermotolerance and heat stress protein synthesis.
title_sort effects of glutathione depletion on thermotolerance and heat stress protein synthesis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976852/
https://www.ncbi.nlm.nih.gov/pubmed/6733022
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