Multiplicative effect of inhaled plutonium oxide and benzo (a) pyrene on lung carcinogenesis in rats.

This study describes the effect of intratracheal instillations (2 X 5 mg) of benzo(a)pyrene (B(a)P) on lung carcinogenesis in rats which had previously inhaled different levels of 239 plutonium oxide (220, 630, 6300 Bq, initial lung burden). Survival decreased with increasing PuO2 exposure and addit...

Descripción completa

Detalles Bibliográficos
Autores principales: Métivier, H., Wahrendorf, J., Masse, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976869/
https://www.ncbi.nlm.nih.gov/pubmed/6087866
_version_ 1782135143461289984
author Métivier, H.
Wahrendorf, J.
Masse, R.
author_facet Métivier, H.
Wahrendorf, J.
Masse, R.
author_sort Métivier, H.
collection PubMed
description This study describes the effect of intratracheal instillations (2 X 5 mg) of benzo(a)pyrene (B(a)P) on lung carcinogenesis in rats which had previously inhaled different levels of 239 plutonium oxide (220, 630, 6300 Bq, initial lung burden). Survival decreased with increasing PuO2 exposure and additional B(a)P exposure. The incidence of malignant lung tumours, adjusted for differences in survival, increased in a dose-related fashion with PuO2 dose and was elevated in the presence of additional B(a)P exposure. A multiplicative relative risk model was found to describe reasonably well the observed joint effect. The practical implications of these findings are discussed.
format Text
id pubmed-1976869
institution National Center for Biotechnology Information
language English
publishDate 1984
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19768692009-09-10 Multiplicative effect of inhaled plutonium oxide and benzo (a) pyrene on lung carcinogenesis in rats. Métivier, H. Wahrendorf, J. Masse, R. Br J Cancer Research Article This study describes the effect of intratracheal instillations (2 X 5 mg) of benzo(a)pyrene (B(a)P) on lung carcinogenesis in rats which had previously inhaled different levels of 239 plutonium oxide (220, 630, 6300 Bq, initial lung burden). Survival decreased with increasing PuO2 exposure and additional B(a)P exposure. The incidence of malignant lung tumours, adjusted for differences in survival, increased in a dose-related fashion with PuO2 dose and was elevated in the presence of additional B(a)P exposure. A multiplicative relative risk model was found to describe reasonably well the observed joint effect. The practical implications of these findings are discussed. Nature Publishing Group 1984-08 /pmc/articles/PMC1976869/ /pubmed/6087866 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Métivier, H.
Wahrendorf, J.
Masse, R.
Multiplicative effect of inhaled plutonium oxide and benzo (a) pyrene on lung carcinogenesis in rats.
title Multiplicative effect of inhaled plutonium oxide and benzo (a) pyrene on lung carcinogenesis in rats.
title_full Multiplicative effect of inhaled plutonium oxide and benzo (a) pyrene on lung carcinogenesis in rats.
title_fullStr Multiplicative effect of inhaled plutonium oxide and benzo (a) pyrene on lung carcinogenesis in rats.
title_full_unstemmed Multiplicative effect of inhaled plutonium oxide and benzo (a) pyrene on lung carcinogenesis in rats.
title_short Multiplicative effect of inhaled plutonium oxide and benzo (a) pyrene on lung carcinogenesis in rats.
title_sort multiplicative effect of inhaled plutonium oxide and benzo (a) pyrene on lung carcinogenesis in rats.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976869/
https://www.ncbi.nlm.nih.gov/pubmed/6087866
work_keys_str_mv AT metivierh multiplicativeeffectofinhaledplutoniumoxideandbenzoapyreneonlungcarcinogenesisinrats
AT wahrendorfj multiplicativeeffectofinhaledplutoniumoxideandbenzoapyreneonlungcarcinogenesisinrats
AT masser multiplicativeeffectofinhaledplutoniumoxideandbenzoapyreneonlungcarcinogenesisinrats

Ejemplares similares