The 1984 Walter Hubert lecture. Activation of transforming genes in neoplasms.

Cellular oncogenes have been identified by the biological activity of tumour DNAs in transfection assays and/or by homology to the transforming genes of retroviruses. In some tumours, the biological activity, organization or expression of these genes is altered, suggesting that such alterations cont...

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Detalles Bibliográficos
Autor principal: Cooper, G. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976883/
https://www.ncbi.nlm.nih.gov/pubmed/6380552
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author Cooper, G. M.
author_facet Cooper, G. M.
author_sort Cooper, G. M.
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description Cellular oncogenes have been identified by the biological activity of tumour DNAs in transfection assays and/or by homology to the transforming genes of retroviruses. In some tumours, the biological activity, organization or expression of these genes is altered, suggesting that such alterations contribute to the development of neoplastic disease. Experiments leading to the identification of cellular oncogenes are reviewed and our current understanding of the mechanisms by which they induce transformation of cells in culture and may contribute to the pathogenesis of neoplasms in vivo is discussed.
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spelling pubmed-19768832009-09-10 The 1984 Walter Hubert lecture. Activation of transforming genes in neoplasms. Cooper, G. M. Br J Cancer Research Article Cellular oncogenes have been identified by the biological activity of tumour DNAs in transfection assays and/or by homology to the transforming genes of retroviruses. In some tumours, the biological activity, organization or expression of these genes is altered, suggesting that such alterations contribute to the development of neoplastic disease. Experiments leading to the identification of cellular oncogenes are reviewed and our current understanding of the mechanisms by which they induce transformation of cells in culture and may contribute to the pathogenesis of neoplasms in vivo is discussed. Nature Publishing Group 1984-08 /pmc/articles/PMC1976883/ /pubmed/6380552 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Cooper, G. M.
The 1984 Walter Hubert lecture. Activation of transforming genes in neoplasms.
title The 1984 Walter Hubert lecture. Activation of transforming genes in neoplasms.
title_full The 1984 Walter Hubert lecture. Activation of transforming genes in neoplasms.
title_fullStr The 1984 Walter Hubert lecture. Activation of transforming genes in neoplasms.
title_full_unstemmed The 1984 Walter Hubert lecture. Activation of transforming genes in neoplasms.
title_short The 1984 Walter Hubert lecture. Activation of transforming genes in neoplasms.
title_sort 1984 walter hubert lecture. activation of transforming genes in neoplasms.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976883/
https://www.ncbi.nlm.nih.gov/pubmed/6380552
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