Effects of haematoporphyrin derivative and light in combination with hyperthermia on cells in culture.

Interactions between the photodynamic effect of haematoporphyrin derivative and hyperthermia are reported. Cells labelled with haematoporphyrin derivative and irradiated with red light were sensitized by heat, particularly when the cells were heated after the exposure to light. It is shown that ther...

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Autores principales: Christensen, T., Wahl, A., Smedshammer, L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976930/
https://www.ncbi.nlm.nih.gov/pubmed/6234913
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author Christensen, T.
Wahl, A.
Smedshammer, L.
author_facet Christensen, T.
Wahl, A.
Smedshammer, L.
author_sort Christensen, T.
collection PubMed
description Interactions between the photodynamic effect of haematoporphyrin derivative and hyperthermia are reported. Cells labelled with haematoporphyrin derivative and irradiated with red light were sensitized by heat, particularly when the cells were heated after the exposure to light. It is shown that there is a synergistic interaction between the photodynamic effect and hyperthermia (42.5 and 45 degrees C). Hyperthermia-induced inhibition of the repair of photodynamic damage is suggested as a mechanism for the interaction. The possibility that these findings may be advantageous to cancer therapy is discussed.
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spelling pubmed-19769302009-09-10 Effects of haematoporphyrin derivative and light in combination with hyperthermia on cells in culture. Christensen, T. Wahl, A. Smedshammer, L. Br J Cancer Research Article Interactions between the photodynamic effect of haematoporphyrin derivative and hyperthermia are reported. Cells labelled with haematoporphyrin derivative and irradiated with red light were sensitized by heat, particularly when the cells were heated after the exposure to light. It is shown that there is a synergistic interaction between the photodynamic effect and hyperthermia (42.5 and 45 degrees C). Hyperthermia-induced inhibition of the repair of photodynamic damage is suggested as a mechanism for the interaction. The possibility that these findings may be advantageous to cancer therapy is discussed. Nature Publishing Group 1984-07 /pmc/articles/PMC1976930/ /pubmed/6234913 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Christensen, T.
Wahl, A.
Smedshammer, L.
Effects of haematoporphyrin derivative and light in combination with hyperthermia on cells in culture.
title Effects of haematoporphyrin derivative and light in combination with hyperthermia on cells in culture.
title_full Effects of haematoporphyrin derivative and light in combination with hyperthermia on cells in culture.
title_fullStr Effects of haematoporphyrin derivative and light in combination with hyperthermia on cells in culture.
title_full_unstemmed Effects of haematoporphyrin derivative and light in combination with hyperthermia on cells in culture.
title_short Effects of haematoporphyrin derivative and light in combination with hyperthermia on cells in culture.
title_sort effects of haematoporphyrin derivative and light in combination with hyperthermia on cells in culture.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976930/
https://www.ncbi.nlm.nih.gov/pubmed/6234913
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AT smedshammerl effectsofhaematoporphyrinderivativeandlightincombinationwithhyperthermiaoncellsinculture

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