HLA and nasopharyngeal carcinoma in Malays.

HLA associations were observed in unrelated Malay patients with nasopharyngeal carcinoma (NPC). HLA-B18 was observed in 18/45 (40%) Malay NPC patients compared to 22/167 (13%) Malay normals (P = 0.0001; Pc = 0.0027, RR = 4.4). The frequency of HLA-B17, one of the antigens associated with Chinese NPC...

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Autores principales: Chan, S. H., Chew, C. T., Prasad, U., Wee, G. B., Srinivasan, N., Kunaratnam, N.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976940/
https://www.ncbi.nlm.nih.gov/pubmed/3855643
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author Chan, S. H.
Chew, C. T.
Prasad, U.
Wee, G. B.
Srinivasan, N.
Kunaratnam, N.
author_facet Chan, S. H.
Chew, C. T.
Prasad, U.
Wee, G. B.
Srinivasan, N.
Kunaratnam, N.
author_sort Chan, S. H.
collection PubMed
description HLA associations were observed in unrelated Malay patients with nasopharyngeal carcinoma (NPC). HLA-B18 was observed in 18/45 (40%) Malay NPC patients compared to 22/167 (13%) Malay normals (P = 0.0001; Pc = 0.0027, RR = 4.4). The frequency of HLA-B17, one of the antigens associated with Chinese NPC, was also increased among Malay NPC (13/45 29%) compared to controls (18/167 11%; P = 0.003, Pc = 0.07 RR = 3.4). Similar to the findings among Chinese NPC, the frequency of B17 was higher in early onset (less than or equal to 30 years) Malay NPC resulting in a higher relative risk (RR = 5.0).
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spelling pubmed-19769402009-09-10 HLA and nasopharyngeal carcinoma in Malays. Chan, S. H. Chew, C. T. Prasad, U. Wee, G. B. Srinivasan, N. Kunaratnam, N. Br J Cancer Research Article HLA associations were observed in unrelated Malay patients with nasopharyngeal carcinoma (NPC). HLA-B18 was observed in 18/45 (40%) Malay NPC patients compared to 22/167 (13%) Malay normals (P = 0.0001; Pc = 0.0027, RR = 4.4). The frequency of HLA-B17, one of the antigens associated with Chinese NPC, was also increased among Malay NPC (13/45 29%) compared to controls (18/167 11%; P = 0.003, Pc = 0.07 RR = 3.4). Similar to the findings among Chinese NPC, the frequency of B17 was higher in early onset (less than or equal to 30 years) Malay NPC resulting in a higher relative risk (RR = 5.0). Nature Publishing Group 1985-03 /pmc/articles/PMC1976940/ /pubmed/3855643 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Chan, S. H.
Chew, C. T.
Prasad, U.
Wee, G. B.
Srinivasan, N.
Kunaratnam, N.
HLA and nasopharyngeal carcinoma in Malays.
title HLA and nasopharyngeal carcinoma in Malays.
title_full HLA and nasopharyngeal carcinoma in Malays.
title_fullStr HLA and nasopharyngeal carcinoma in Malays.
title_full_unstemmed HLA and nasopharyngeal carcinoma in Malays.
title_short HLA and nasopharyngeal carcinoma in Malays.
title_sort hla and nasopharyngeal carcinoma in malays.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976940/
https://www.ncbi.nlm.nih.gov/pubmed/3855643
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