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Goblet cell changes during intestinal adaptation to azoxymethane and enteric bypass in the rat.

Numbers of intestinal goblet cells containing specific acid mucins were determined in male Sprague-Dawley rats receiving azoxymethane (total dose 90 mg kg-1) with or without jejunoileal bypass (JIB). Controls had injections of vehicle and sham bypass. Thirty weeks postoperatively colorectal length a...

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Autores principales: Olubuyide, I. O., Bristol, J. B., Williamson, R. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976952/
https://www.ncbi.nlm.nih.gov/pubmed/3970814
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author Olubuyide, I. O.
Bristol, J. B.
Williamson, R. C.
author_facet Olubuyide, I. O.
Bristol, J. B.
Williamson, R. C.
author_sort Olubuyide, I. O.
collection PubMed
description Numbers of intestinal goblet cells containing specific acid mucins were determined in male Sprague-Dawley rats receiving azoxymethane (total dose 90 mg kg-1) with or without jejunoileal bypass (JIB). Controls had injections of vehicle and sham bypass. Thirty weeks postoperatively colorectal length and crypt depth were increased by azoxymethane and further increased by JIB. JIB doubled the yield of intestinal tumours (P less than 0.01). Goblet cells containing sulphomucins normally predominated throughout the intestinal tract. Contents of sulphomucins and especially sialomucins were consistently higher in the small bowel and colon of rats receiving azoxymethane alone, but again the highest values were observed in animals with azoxymethane plus JIB. Both small-bowel bypass and azoxymethane stimulate adaptive growth of the colon and small bowel remaining in circuit. Goblet-cell hyperplasia is a feature of this response, and sialomucins are preferentially secreted by the adapting epithelium. IMAGES:
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spelling pubmed-19769522009-09-10 Goblet cell changes during intestinal adaptation to azoxymethane and enteric bypass in the rat. Olubuyide, I. O. Bristol, J. B. Williamson, R. C. Br J Cancer Research Article Numbers of intestinal goblet cells containing specific acid mucins were determined in male Sprague-Dawley rats receiving azoxymethane (total dose 90 mg kg-1) with or without jejunoileal bypass (JIB). Controls had injections of vehicle and sham bypass. Thirty weeks postoperatively colorectal length and crypt depth were increased by azoxymethane and further increased by JIB. JIB doubled the yield of intestinal tumours (P less than 0.01). Goblet cells containing sulphomucins normally predominated throughout the intestinal tract. Contents of sulphomucins and especially sialomucins were consistently higher in the small bowel and colon of rats receiving azoxymethane alone, but again the highest values were observed in animals with azoxymethane plus JIB. Both small-bowel bypass and azoxymethane stimulate adaptive growth of the colon and small bowel remaining in circuit. Goblet-cell hyperplasia is a feature of this response, and sialomucins are preferentially secreted by the adapting epithelium. IMAGES: Nature Publishing Group 1985-03 /pmc/articles/PMC1976952/ /pubmed/3970814 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Olubuyide, I. O.
Bristol, J. B.
Williamson, R. C.
Goblet cell changes during intestinal adaptation to azoxymethane and enteric bypass in the rat.
title Goblet cell changes during intestinal adaptation to azoxymethane and enteric bypass in the rat.
title_full Goblet cell changes during intestinal adaptation to azoxymethane and enteric bypass in the rat.
title_fullStr Goblet cell changes during intestinal adaptation to azoxymethane and enteric bypass in the rat.
title_full_unstemmed Goblet cell changes during intestinal adaptation to azoxymethane and enteric bypass in the rat.
title_short Goblet cell changes during intestinal adaptation to azoxymethane and enteric bypass in the rat.
title_sort goblet cell changes during intestinal adaptation to azoxymethane and enteric bypass in the rat.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976952/
https://www.ncbi.nlm.nih.gov/pubmed/3970814
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