Ovarian tumour xenografts in the study of the biology of human epithelial ovarian cancer.

Human epithelial ovarian tumours were successfully established as xenografts in nude mice in 54% of cases. An evaluation of the biological characteristics of tumours propagated in nude mice was carried out and the functions investigated included morphology, growth kinetics, cellular DNA content, cel...

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Detalles Bibliográficos
Autores principales: Friedlander, M. L., Russell, P., Taylor, I. W., Tattersall, M. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976954/
https://www.ncbi.nlm.nih.gov/pubmed/3882111
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author Friedlander, M. L.
Russell, P.
Taylor, I. W.
Tattersall, M. H.
author_facet Friedlander, M. L.
Russell, P.
Taylor, I. W.
Tattersall, M. H.
author_sort Friedlander, M. L.
collection PubMed
description Human epithelial ovarian tumours were successfully established as xenografts in nude mice in 54% of cases. An evaluation of the biological characteristics of tumours propagated in nude mice was carried out and the functions investigated included morphology, growth kinetics, cellular DNA content, cell surface antigen expression and sensitivity to chemotherapy. To allow a more detailed study of the influence of ploidy on biological behaviour, xenografted tumour with varying degrees of aneuploidy and tumours with a common ancestry but different ploidies were also established. Although this is a highly selective model system favouring the growth of biologically aggressive tumours the xenografts, in general, reflect many of the characteristics of the tumours from which they were derived and are likely to provide a useful model for investigating the biology of ovarian cancer. IMAGES:
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spelling pubmed-19769542009-09-10 Ovarian tumour xenografts in the study of the biology of human epithelial ovarian cancer. Friedlander, M. L. Russell, P. Taylor, I. W. Tattersall, M. H. Br J Cancer Research Article Human epithelial ovarian tumours were successfully established as xenografts in nude mice in 54% of cases. An evaluation of the biological characteristics of tumours propagated in nude mice was carried out and the functions investigated included morphology, growth kinetics, cellular DNA content, cell surface antigen expression and sensitivity to chemotherapy. To allow a more detailed study of the influence of ploidy on biological behaviour, xenografted tumour with varying degrees of aneuploidy and tumours with a common ancestry but different ploidies were also established. Although this is a highly selective model system favouring the growth of biologically aggressive tumours the xenografts, in general, reflect many of the characteristics of the tumours from which they were derived and are likely to provide a useful model for investigating the biology of ovarian cancer. IMAGES: Nature Publishing Group 1985-03 /pmc/articles/PMC1976954/ /pubmed/3882111 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Friedlander, M. L.
Russell, P.
Taylor, I. W.
Tattersall, M. H.
Ovarian tumour xenografts in the study of the biology of human epithelial ovarian cancer.
title Ovarian tumour xenografts in the study of the biology of human epithelial ovarian cancer.
title_full Ovarian tumour xenografts in the study of the biology of human epithelial ovarian cancer.
title_fullStr Ovarian tumour xenografts in the study of the biology of human epithelial ovarian cancer.
title_full_unstemmed Ovarian tumour xenografts in the study of the biology of human epithelial ovarian cancer.
title_short Ovarian tumour xenografts in the study of the biology of human epithelial ovarian cancer.
title_sort ovarian tumour xenografts in the study of the biology of human epithelial ovarian cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976954/
https://www.ncbi.nlm.nih.gov/pubmed/3882111
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