Inhibition of the recovery from potentially lethal damage by lonidamine.

Lonidamine [1-(2,4-dichlorobenzyl)-1-H-indazol-3-carboxylic acid] is shown to inhibit recovery from potentially lethal damage after exposure of cells to X-rays, methyl methane sulfonate, or bleomycin and heat (43 degrees C, 1h). Inhibition is most effective when the drug is present before and after...

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Detalles Bibliográficos
Autores principales: Hahn, G. M., van Kersen, I., Silvestrini, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976972/
https://www.ncbi.nlm.nih.gov/pubmed/6208924
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author Hahn, G. M.
van Kersen, I.
Silvestrini, B.
author_facet Hahn, G. M.
van Kersen, I.
Silvestrini, B.
author_sort Hahn, G. M.
collection PubMed
description Lonidamine [1-(2,4-dichlorobenzyl)-1-H-indazol-3-carboxylic acid] is shown to inhibit recovery from potentially lethal damage after exposure of cells to X-rays, methyl methane sulfonate, or bleomycin and heat (43 degrees C, 1h). Inhibition is most effective when the drug is present before and after exposure of 10 to 25 mg l-1, a concentration readily achievable in vivo.
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spelling pubmed-19769722009-09-10 Inhibition of the recovery from potentially lethal damage by lonidamine. Hahn, G. M. van Kersen, I. Silvestrini, B. Br J Cancer Research Article Lonidamine [1-(2,4-dichlorobenzyl)-1-H-indazol-3-carboxylic acid] is shown to inhibit recovery from potentially lethal damage after exposure of cells to X-rays, methyl methane sulfonate, or bleomycin and heat (43 degrees C, 1h). Inhibition is most effective when the drug is present before and after exposure of 10 to 25 mg l-1, a concentration readily achievable in vivo. Nature Publishing Group 1984-11 /pmc/articles/PMC1976972/ /pubmed/6208924 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hahn, G. M.
van Kersen, I.
Silvestrini, B.
Inhibition of the recovery from potentially lethal damage by lonidamine.
title Inhibition of the recovery from potentially lethal damage by lonidamine.
title_full Inhibition of the recovery from potentially lethal damage by lonidamine.
title_fullStr Inhibition of the recovery from potentially lethal damage by lonidamine.
title_full_unstemmed Inhibition of the recovery from potentially lethal damage by lonidamine.
title_short Inhibition of the recovery from potentially lethal damage by lonidamine.
title_sort inhibition of the recovery from potentially lethal damage by lonidamine.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976972/
https://www.ncbi.nlm.nih.gov/pubmed/6208924
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AT silvestrinib inhibitionoftherecoveryfrompotentiallylethaldamagebylonidamine

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