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Cutaneous malignant melanoma in women: exogenous sex hormones and reproductive factors.
The roles of exogenous sex hormones and reproductive factors in the causation of malignant melanoma of the skin in women were examined in a case-control study of 276 patients and 276 matched controls in Western Australia. There was no consistent evidence of a relationship between the incidence rates...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1984
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976990/ https://www.ncbi.nlm.nih.gov/pubmed/6498065 |
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author | Holman, C. D. Armstrong, B. K. Heenan, P. J. |
author_facet | Holman, C. D. Armstrong, B. K. Heenan, P. J. |
author_sort | Holman, C. D. |
collection | PubMed |
description | The roles of exogenous sex hormones and reproductive factors in the causation of malignant melanoma of the skin in women were examined in a case-control study of 276 patients and 276 matched controls in Western Australia. There was no consistent evidence of a relationship between the incidence rates of different histogenetic types of melanoma and age at menarche, duration of menstrual life, degree of obesity, number of pregnancies more than 20 weeks in duration or use of oral contraceptive preparations (OCP). Exposure to OCP was examined separately for different age periods and in different intervals of time before diagnosis; no consistent trend emerged. There was borderline evidence of an association of superficial spreading melanoma with duration of use of unopposed oestrogens. On the basis of seven studies of the relationship of melanoma to OCP published to date, we estimate that the total incidence rate of melanoma in OCP ever-users is unlikely to be increased by more than one third the rate in never-users. |
format | Text |
id | pubmed-1976990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1984 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-19769902009-09-10 Cutaneous malignant melanoma in women: exogenous sex hormones and reproductive factors. Holman, C. D. Armstrong, B. K. Heenan, P. J. Br J Cancer Research Article The roles of exogenous sex hormones and reproductive factors in the causation of malignant melanoma of the skin in women were examined in a case-control study of 276 patients and 276 matched controls in Western Australia. There was no consistent evidence of a relationship between the incidence rates of different histogenetic types of melanoma and age at menarche, duration of menstrual life, degree of obesity, number of pregnancies more than 20 weeks in duration or use of oral contraceptive preparations (OCP). Exposure to OCP was examined separately for different age periods and in different intervals of time before diagnosis; no consistent trend emerged. There was borderline evidence of an association of superficial spreading melanoma with duration of use of unopposed oestrogens. On the basis of seven studies of the relationship of melanoma to OCP published to date, we estimate that the total incidence rate of melanoma in OCP ever-users is unlikely to be increased by more than one third the rate in never-users. Nature Publishing Group 1984-11 /pmc/articles/PMC1976990/ /pubmed/6498065 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Holman, C. D. Armstrong, B. K. Heenan, P. J. Cutaneous malignant melanoma in women: exogenous sex hormones and reproductive factors. |
title | Cutaneous malignant melanoma in women: exogenous sex hormones and reproductive factors. |
title_full | Cutaneous malignant melanoma in women: exogenous sex hormones and reproductive factors. |
title_fullStr | Cutaneous malignant melanoma in women: exogenous sex hormones and reproductive factors. |
title_full_unstemmed | Cutaneous malignant melanoma in women: exogenous sex hormones and reproductive factors. |
title_short | Cutaneous malignant melanoma in women: exogenous sex hormones and reproductive factors. |
title_sort | cutaneous malignant melanoma in women: exogenous sex hormones and reproductive factors. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976990/ https://www.ncbi.nlm.nih.gov/pubmed/6498065 |
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