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Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.

Forty patients with metastatic adenocarcinoma of the prostate were evaluated for response to treatment with aminoglutethimide plus cortisone acetate. All had relapsed from or failed to respond to primary endocrine treatment with orchidectomy or stilboestrol. Nineteen patients (48%) showed subjective...

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Detalles Bibliográficos
Autores principales: Ponder, B. A., Shearer, R. J., Pocock, R. D., Miller, J., Easton, D., Chilvers, C. E., Dowsett, M., Jeffcoate, S. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1984
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977020/
https://www.ncbi.nlm.nih.gov/pubmed/6238616
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author Ponder, B. A.
Shearer, R. J.
Pocock, R. D.
Miller, J.
Easton, D.
Chilvers, C. E.
Dowsett, M.
Jeffcoate, S. L.
author_facet Ponder, B. A.
Shearer, R. J.
Pocock, R. D.
Miller, J.
Easton, D.
Chilvers, C. E.
Dowsett, M.
Jeffcoate, S. L.
author_sort Ponder, B. A.
collection PubMed
description Forty patients with metastatic adenocarcinoma of the prostate were evaluated for response to treatment with aminoglutethimide plus cortisone acetate. All had relapsed from or failed to respond to primary endocrine treatment with orchidectomy or stilboestrol. Nineteen patients (48%) showed subjective response, in most cases relief of bone pain. Side effects limited treatment in only 3 patients. We conclude that aminoglutethimide plus cortisone acetate is a useful addition to the treatment available for this difficult group of patients. The mechanism by which this treatment has a beneficial effect remains unclear.
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spelling pubmed-19770202009-09-10 Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer. Ponder, B. A. Shearer, R. J. Pocock, R. D. Miller, J. Easton, D. Chilvers, C. E. Dowsett, M. Jeffcoate, S. L. Br J Cancer Research Article Forty patients with metastatic adenocarcinoma of the prostate were evaluated for response to treatment with aminoglutethimide plus cortisone acetate. All had relapsed from or failed to respond to primary endocrine treatment with orchidectomy or stilboestrol. Nineteen patients (48%) showed subjective response, in most cases relief of bone pain. Side effects limited treatment in only 3 patients. We conclude that aminoglutethimide plus cortisone acetate is a useful addition to the treatment available for this difficult group of patients. The mechanism by which this treatment has a beneficial effect remains unclear. Nature Publishing Group 1984-12 /pmc/articles/PMC1977020/ /pubmed/6238616 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ponder, B. A.
Shearer, R. J.
Pocock, R. D.
Miller, J.
Easton, D.
Chilvers, C. E.
Dowsett, M.
Jeffcoate, S. L.
Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
title Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
title_full Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
title_fullStr Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
title_full_unstemmed Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
title_short Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
title_sort response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977020/
https://www.ncbi.nlm.nih.gov/pubmed/6238616
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