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Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
Forty patients with metastatic adenocarcinoma of the prostate were evaluated for response to treatment with aminoglutethimide plus cortisone acetate. All had relapsed from or failed to respond to primary endocrine treatment with orchidectomy or stilboestrol. Nineteen patients (48%) showed subjective...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1984
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977020/ https://www.ncbi.nlm.nih.gov/pubmed/6238616 |
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author | Ponder, B. A. Shearer, R. J. Pocock, R. D. Miller, J. Easton, D. Chilvers, C. E. Dowsett, M. Jeffcoate, S. L. |
author_facet | Ponder, B. A. Shearer, R. J. Pocock, R. D. Miller, J. Easton, D. Chilvers, C. E. Dowsett, M. Jeffcoate, S. L. |
author_sort | Ponder, B. A. |
collection | PubMed |
description | Forty patients with metastatic adenocarcinoma of the prostate were evaluated for response to treatment with aminoglutethimide plus cortisone acetate. All had relapsed from or failed to respond to primary endocrine treatment with orchidectomy or stilboestrol. Nineteen patients (48%) showed subjective response, in most cases relief of bone pain. Side effects limited treatment in only 3 patients. We conclude that aminoglutethimide plus cortisone acetate is a useful addition to the treatment available for this difficult group of patients. The mechanism by which this treatment has a beneficial effect remains unclear. |
format | Text |
id | pubmed-1977020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1984 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-19770202009-09-10 Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer. Ponder, B. A. Shearer, R. J. Pocock, R. D. Miller, J. Easton, D. Chilvers, C. E. Dowsett, M. Jeffcoate, S. L. Br J Cancer Research Article Forty patients with metastatic adenocarcinoma of the prostate were evaluated for response to treatment with aminoglutethimide plus cortisone acetate. All had relapsed from or failed to respond to primary endocrine treatment with orchidectomy or stilboestrol. Nineteen patients (48%) showed subjective response, in most cases relief of bone pain. Side effects limited treatment in only 3 patients. We conclude that aminoglutethimide plus cortisone acetate is a useful addition to the treatment available for this difficult group of patients. The mechanism by which this treatment has a beneficial effect remains unclear. Nature Publishing Group 1984-12 /pmc/articles/PMC1977020/ /pubmed/6238616 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Ponder, B. A. Shearer, R. J. Pocock, R. D. Miller, J. Easton, D. Chilvers, C. E. Dowsett, M. Jeffcoate, S. L. Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer. |
title | Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer. |
title_full | Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer. |
title_fullStr | Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer. |
title_full_unstemmed | Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer. |
title_short | Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer. |
title_sort | response to aminoglutethimide and cortisone acetate in advanced prostatic cancer. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977020/ https://www.ncbi.nlm.nih.gov/pubmed/6238616 |
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