Chromosomal analysis of neuroblastoma.

Ten children with abdominal neuroblastoma were included in the study. Biopsies from the neuroblastomas were taken during surgical operations, nine from the primary tumours and one from a metastasis. Histopathology was done for diagnosis. Chromosomal cultures of neuroblastoma cells and peripheral blo...

Descripción completa

Detalles Bibliográficos
Autores principales: Hafez, M., el-Meadday, M., Sheir, M., Al-Tonbarry, Y., Nada, N., el-Desoky, I.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977036/
https://www.ncbi.nlm.nih.gov/pubmed/3966981
_version_ 1782135176912961536
author Hafez, M.
el-Meadday, M.
Sheir, M.
Al-Tonbarry, Y.
Nada, N.
el-Desoky, I.
author_facet Hafez, M.
el-Meadday, M.
Sheir, M.
Al-Tonbarry, Y.
Nada, N.
el-Desoky, I.
author_sort Hafez, M.
collection PubMed
description Ten children with abdominal neuroblastoma were included in the study. Biopsies from the neuroblastomas were taken during surgical operations, nine from the primary tumours and one from a metastasis. Histopathology was done for diagnosis. Chromosomal cultures of neuroblastoma cells and peripheral blood lymphocytes were performed. The peripheral blood lymphocytes revealed normal chromosomal complements. The 10 tumours were in the peridiploid range with random gains or losses of chromosomes. Deletion of the short arm of chromosome number 1 distal to band p31 occurred in 6 tumours. Other structural changes and giant markers were found. It was concluded that a regulatory gene controlling the transformation gene of neuroblastoma, is present at or distal to lp31. IMAGES:
format Text
id pubmed-1977036
institution National Center for Biotechnology Information
language English
publishDate 1985
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19770362009-09-10 Chromosomal analysis of neuroblastoma. Hafez, M. el-Meadday, M. Sheir, M. Al-Tonbarry, Y. Nada, N. el-Desoky, I. Br J Cancer Research Article Ten children with abdominal neuroblastoma were included in the study. Biopsies from the neuroblastomas were taken during surgical operations, nine from the primary tumours and one from a metastasis. Histopathology was done for diagnosis. Chromosomal cultures of neuroblastoma cells and peripheral blood lymphocytes were performed. The peripheral blood lymphocytes revealed normal chromosomal complements. The 10 tumours were in the peridiploid range with random gains or losses of chromosomes. Deletion of the short arm of chromosome number 1 distal to band p31 occurred in 6 tumours. Other structural changes and giant markers were found. It was concluded that a regulatory gene controlling the transformation gene of neuroblastoma, is present at or distal to lp31. IMAGES: Nature Publishing Group 1985-02 /pmc/articles/PMC1977036/ /pubmed/3966981 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hafez, M.
el-Meadday, M.
Sheir, M.
Al-Tonbarry, Y.
Nada, N.
el-Desoky, I.
Chromosomal analysis of neuroblastoma.
title Chromosomal analysis of neuroblastoma.
title_full Chromosomal analysis of neuroblastoma.
title_fullStr Chromosomal analysis of neuroblastoma.
title_full_unstemmed Chromosomal analysis of neuroblastoma.
title_short Chromosomal analysis of neuroblastoma.
title_sort chromosomal analysis of neuroblastoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977036/
https://www.ncbi.nlm.nih.gov/pubmed/3966981
work_keys_str_mv AT hafezm chromosomalanalysisofneuroblastoma
AT elmeaddaym chromosomalanalysisofneuroblastoma
AT sheirm chromosomalanalysisofneuroblastoma
AT altonbarryy chromosomalanalysisofneuroblastoma
AT nadan chromosomalanalysisofneuroblastoma
AT eldesokyi chromosomalanalysisofneuroblastoma

Ejemplares similares