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Treatment of malignant hypercalcaemia with clodronate.
We have assessed the effects of clodronate (dichloromethylene diphosphonate; Cl2MDP 0.8-3.2g daily by mouth for up to 3 months) in 17 episodes of hypercalcaemia and osteolysis due to carcinoma. Clodronate reduced serum calcium in 14 episodes and bone resorption in all patients. These remained suppre...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
1985
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977044/ https://www.ncbi.nlm.nih.gov/pubmed/3158326 |
| _version_ | 1782135178790961152 |
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| author | Percival, R. C. Paterson, A. D. Yates, A. J. Beard, D. J. Douglas, D. L. Neal, F. E. Russell, R. G. Kanis, J. A. |
| author_facet | Percival, R. C. Paterson, A. D. Yates, A. J. Beard, D. J. Douglas, D. L. Neal, F. E. Russell, R. G. Kanis, J. A. |
| author_sort | Percival, R. C. |
| collection | PubMed |
| description | We have assessed the effects of clodronate (dichloromethylene diphosphonate; Cl2MDP 0.8-3.2g daily by mouth for up to 3 months) in 17 episodes of hypercalcaemia and osteolysis due to carcinoma. Clodronate reduced serum calcium in 14 episodes and bone resorption in all patients. These remained suppressed for the duration of treatment, but recurred promptly when treatment was stopped. Clodronate may be a useful measure for controlling hypercalcaemia and osteolysis in patients with carcinoma. |
| format | Text |
| id | pubmed-1977044 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1985 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-19770442009-09-10 Treatment of malignant hypercalcaemia with clodronate. Percival, R. C. Paterson, A. D. Yates, A. J. Beard, D. J. Douglas, D. L. Neal, F. E. Russell, R. G. Kanis, J. A. Br J Cancer Research Article We have assessed the effects of clodronate (dichloromethylene diphosphonate; Cl2MDP 0.8-3.2g daily by mouth for up to 3 months) in 17 episodes of hypercalcaemia and osteolysis due to carcinoma. Clodronate reduced serum calcium in 14 episodes and bone resorption in all patients. These remained suppressed for the duration of treatment, but recurred promptly when treatment was stopped. Clodronate may be a useful measure for controlling hypercalcaemia and osteolysis in patients with carcinoma. Nature Publishing Group 1985-05 /pmc/articles/PMC1977044/ /pubmed/3158326 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Research Article Percival, R. C. Paterson, A. D. Yates, A. J. Beard, D. J. Douglas, D. L. Neal, F. E. Russell, R. G. Kanis, J. A. Treatment of malignant hypercalcaemia with clodronate. |
| title | Treatment of malignant hypercalcaemia with clodronate. |
| title_full | Treatment of malignant hypercalcaemia with clodronate. |
| title_fullStr | Treatment of malignant hypercalcaemia with clodronate. |
| title_full_unstemmed | Treatment of malignant hypercalcaemia with clodronate. |
| title_short | Treatment of malignant hypercalcaemia with clodronate. |
| title_sort | treatment of malignant hypercalcaemia with clodronate. |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977044/ https://www.ncbi.nlm.nih.gov/pubmed/3158326 |
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