Placental alkaline phosphatase as a tumour marker in seminoma using the H17 E2 monoclonal antibody assay.

Serum samples from 62 patients with seminoma were assayed for placental alkaline phosphatase-like activity using the monoclonal antibody H17 E2, in order to evaluate its utility as a serum tumour marker. Fifteen of 16 patients (94%) with active seminoma had elevated serum PLAP levels. Sixteen of 46...

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Autores principales: Horwich, A., Tucker, D. F., Peckham, M. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977054/
https://www.ncbi.nlm.nih.gov/pubmed/3994907
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author Horwich, A.
Tucker, D. F.
Peckham, M. J.
author_facet Horwich, A.
Tucker, D. F.
Peckham, M. J.
author_sort Horwich, A.
collection PubMed
description Serum samples from 62 patients with seminoma were assayed for placental alkaline phosphatase-like activity using the monoclonal antibody H17 E2, in order to evaluate its utility as a serum tumour marker. Fifteen of 16 patients (94%) with active seminoma had elevated serum PLAP levels. Sixteen of 46 (35%) of patients considered to be in remission had elevated PLAP levels (false positive rate 35%). Fifteen false positive results were considered attributable to concomitant smoking, and if these patients are excluded, only one false positive case was detected. In 7 out of 7 patients sequential PLAP assays reflected clinical response to treatment.
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spelling pubmed-19770542009-09-10 Placental alkaline phosphatase as a tumour marker in seminoma using the H17 E2 monoclonal antibody assay. Horwich, A. Tucker, D. F. Peckham, M. J. Br J Cancer Research Article Serum samples from 62 patients with seminoma were assayed for placental alkaline phosphatase-like activity using the monoclonal antibody H17 E2, in order to evaluate its utility as a serum tumour marker. Fifteen of 16 patients (94%) with active seminoma had elevated serum PLAP levels. Sixteen of 46 (35%) of patients considered to be in remission had elevated PLAP levels (false positive rate 35%). Fifteen false positive results were considered attributable to concomitant smoking, and if these patients are excluded, only one false positive case was detected. In 7 out of 7 patients sequential PLAP assays reflected clinical response to treatment. Nature Publishing Group 1985-05 /pmc/articles/PMC1977054/ /pubmed/3994907 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Horwich, A.
Tucker, D. F.
Peckham, M. J.
Placental alkaline phosphatase as a tumour marker in seminoma using the H17 E2 monoclonal antibody assay.
title Placental alkaline phosphatase as a tumour marker in seminoma using the H17 E2 monoclonal antibody assay.
title_full Placental alkaline phosphatase as a tumour marker in seminoma using the H17 E2 monoclonal antibody assay.
title_fullStr Placental alkaline phosphatase as a tumour marker in seminoma using the H17 E2 monoclonal antibody assay.
title_full_unstemmed Placental alkaline phosphatase as a tumour marker in seminoma using the H17 E2 monoclonal antibody assay.
title_short Placental alkaline phosphatase as a tumour marker in seminoma using the H17 E2 monoclonal antibody assay.
title_sort placental alkaline phosphatase as a tumour marker in seminoma using the h17 e2 monoclonal antibody assay.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977054/
https://www.ncbi.nlm.nih.gov/pubmed/3994907
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AT peckhammj placentalalkalinephosphataseasatumourmarkerinseminomausingtheh17e2monoclonalantibodyassay

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