An immunohistological study of HLA antigen expression by gestational choriocarcinoma.

Two cases of gestational choriocarcinoma have been examined for the expression of HLA and trophoblast antigens using the indirect immunoperoxidase technique on frozen tissue sections. Approximately 40-70% of tumour cells express MHC Class I antigen as detected by a panel of antibodies to monomorphic...

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Autores principales: Sunderland, C. A., Sasagawa, M., Kanazawa, K., Stirrat, G. M., Takeuchi, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977071/
https://www.ncbi.nlm.nih.gov/pubmed/2408648
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author Sunderland, C. A.
Sasagawa, M.
Kanazawa, K.
Stirrat, G. M.
Takeuchi, S.
author_facet Sunderland, C. A.
Sasagawa, M.
Kanazawa, K.
Stirrat, G. M.
Takeuchi, S.
author_sort Sunderland, C. A.
collection PubMed
description Two cases of gestational choriocarcinoma have been examined for the expression of HLA and trophoblast antigens using the indirect immunoperoxidase technique on frozen tissue sections. Approximately 40-70% of tumour cells express MHC Class I antigen as detected by a panel of antibodies to monomorphic, or framework, MHC Class I antigenic determinants. Evidence in one case suggests that most of these cells may not express the paternal, polymorphic HLA antigenic determinants but that a small subpopulation do carry the fully antigenically active molecule. These latter may give rise to patient anti-paternal HLA antibodies. Class II (HLA DR or DC) antigens are expressed by none, or very few, tumour cells. IMAGES:
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spelling pubmed-19770712009-09-10 An immunohistological study of HLA antigen expression by gestational choriocarcinoma. Sunderland, C. A. Sasagawa, M. Kanazawa, K. Stirrat, G. M. Takeuchi, S. Br J Cancer Research Article Two cases of gestational choriocarcinoma have been examined for the expression of HLA and trophoblast antigens using the indirect immunoperoxidase technique on frozen tissue sections. Approximately 40-70% of tumour cells express MHC Class I antigen as detected by a panel of antibodies to monomorphic, or framework, MHC Class I antigenic determinants. Evidence in one case suggests that most of these cells may not express the paternal, polymorphic HLA antigenic determinants but that a small subpopulation do carry the fully antigenically active molecule. These latter may give rise to patient anti-paternal HLA antibodies. Class II (HLA DR or DC) antigens are expressed by none, or very few, tumour cells. IMAGES: Nature Publishing Group 1985-06 /pmc/articles/PMC1977071/ /pubmed/2408648 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Sunderland, C. A.
Sasagawa, M.
Kanazawa, K.
Stirrat, G. M.
Takeuchi, S.
An immunohistological study of HLA antigen expression by gestational choriocarcinoma.
title An immunohistological study of HLA antigen expression by gestational choriocarcinoma.
title_full An immunohistological study of HLA antigen expression by gestational choriocarcinoma.
title_fullStr An immunohistological study of HLA antigen expression by gestational choriocarcinoma.
title_full_unstemmed An immunohistological study of HLA antigen expression by gestational choriocarcinoma.
title_short An immunohistological study of HLA antigen expression by gestational choriocarcinoma.
title_sort immunohistological study of hla antigen expression by gestational choriocarcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977071/
https://www.ncbi.nlm.nih.gov/pubmed/2408648
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