The uptake of alpha-foetoprotein by C-1300 mouse neuroblastoma cells.

Recent immunocytochemical and biochemical studies have shown the intracellular uptake of alpha-foetoprotein (AFP) by most neural crest and neural tube derivatives of developing mammals and birds. The neural crest origin of neuroblastomas has been known for a long time. While many mouse neuroblastoma...

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Autores principales: Hajeri-Germond, M., Naval, J., Trojan, J., Uriel, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977076/
https://www.ncbi.nlm.nih.gov/pubmed/2408647
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author Hajeri-Germond, M.
Naval, J.
Trojan, J.
Uriel, J.
author_facet Hajeri-Germond, M.
Naval, J.
Trojan, J.
Uriel, J.
author_sort Hajeri-Germond, M.
collection PubMed
description Recent immunocytochemical and biochemical studies have shown the intracellular uptake of alpha-foetoprotein (AFP) by most neural crest and neural tube derivatives of developing mammals and birds. The neural crest origin of neuroblastomas has been known for a long time. While many mouse neuroblastoma cell lines can express several neuronal properties, other lines lack specialized neural functions and may re-express embryonal or foetal antigens, suggesting some reversion towards an earlier stage of differentiation. We have therefore tested the C-1300 Jackson mouse neuroblastoma cell line for its ability to incorporate AFP. The results obtained confirm the significant internalization of protein by these cells, both in vitro and in vivo. External photoscans of mice bearing tumours after injection with [131I]-AFP have proven the usefulness of the protein as a radiotracer for neuroblastoma localization. IMAGES:
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spelling pubmed-19770762009-09-10 The uptake of alpha-foetoprotein by C-1300 mouse neuroblastoma cells. Hajeri-Germond, M. Naval, J. Trojan, J. Uriel, J. Br J Cancer Research Article Recent immunocytochemical and biochemical studies have shown the intracellular uptake of alpha-foetoprotein (AFP) by most neural crest and neural tube derivatives of developing mammals and birds. The neural crest origin of neuroblastomas has been known for a long time. While many mouse neuroblastoma cell lines can express several neuronal properties, other lines lack specialized neural functions and may re-express embryonal or foetal antigens, suggesting some reversion towards an earlier stage of differentiation. We have therefore tested the C-1300 Jackson mouse neuroblastoma cell line for its ability to incorporate AFP. The results obtained confirm the significant internalization of protein by these cells, both in vitro and in vivo. External photoscans of mice bearing tumours after injection with [131I]-AFP have proven the usefulness of the protein as a radiotracer for neuroblastoma localization. IMAGES: Nature Publishing Group 1985-06 /pmc/articles/PMC1977076/ /pubmed/2408647 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hajeri-Germond, M.
Naval, J.
Trojan, J.
Uriel, J.
The uptake of alpha-foetoprotein by C-1300 mouse neuroblastoma cells.
title The uptake of alpha-foetoprotein by C-1300 mouse neuroblastoma cells.
title_full The uptake of alpha-foetoprotein by C-1300 mouse neuroblastoma cells.
title_fullStr The uptake of alpha-foetoprotein by C-1300 mouse neuroblastoma cells.
title_full_unstemmed The uptake of alpha-foetoprotein by C-1300 mouse neuroblastoma cells.
title_short The uptake of alpha-foetoprotein by C-1300 mouse neuroblastoma cells.
title_sort uptake of alpha-foetoprotein by c-1300 mouse neuroblastoma cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977076/
https://www.ncbi.nlm.nih.gov/pubmed/2408647
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