The value of immunocytochemical methods in the differential diagnosis of anaplastic thyroid tumours.

The practical usefulness of a panel of monoclonal antibodies recognising epithelial and lymphoid antigens has been evaluated on a series of 10 routinely processed thyroid tumours of uncertain origin. All 6 small cell tumours were shown to be of lymphoid origin whereas of the 4 large cell tumours two...

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Autores principales: Ralfkiaer, N., Gatter, K. C., Alcock, C., Heryet, A., Ralfkiaer, E., Mason, D. Y.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977107/
https://www.ncbi.nlm.nih.gov/pubmed/3896289
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author Ralfkiaer, N.
Gatter, K. C.
Alcock, C.
Heryet, A.
Ralfkiaer, E.
Mason, D. Y.
author_facet Ralfkiaer, N.
Gatter, K. C.
Alcock, C.
Heryet, A.
Ralfkiaer, E.
Mason, D. Y.
author_sort Ralfkiaer, N.
collection PubMed
description The practical usefulness of a panel of monoclonal antibodies recognising epithelial and lymphoid antigens has been evaluated on a series of 10 routinely processed thyroid tumours of uncertain origin. All 6 small cell tumours were shown to be of lymphoid origin whereas of the 4 large cell tumours two were lymphomas and two carcinomas. Two of the tumours, one large cell and one small cell, were undiagnosable due to technical reasons (crush artefact or small size of biopsy) and emphasized the value of immunohistology in this context. Clinical follow-up of all 10 cases indicated that these distinctions are of both prognostic and therapeutic value. It is concluded that immunocytochemistry using a carefully selected panel of monoclonal antibodies is a valuable and convenient means of making an objective distinction between anaplastic thyroid tumours of epithelial or lymphoid origin. IMAGES:
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spelling pubmed-19771072009-09-10 The value of immunocytochemical methods in the differential diagnosis of anaplastic thyroid tumours. Ralfkiaer, N. Gatter, K. C. Alcock, C. Heryet, A. Ralfkiaer, E. Mason, D. Y. Br J Cancer Research Article The practical usefulness of a panel of monoclonal antibodies recognising epithelial and lymphoid antigens has been evaluated on a series of 10 routinely processed thyroid tumours of uncertain origin. All 6 small cell tumours were shown to be of lymphoid origin whereas of the 4 large cell tumours two were lymphomas and two carcinomas. Two of the tumours, one large cell and one small cell, were undiagnosable due to technical reasons (crush artefact or small size of biopsy) and emphasized the value of immunohistology in this context. Clinical follow-up of all 10 cases indicated that these distinctions are of both prognostic and therapeutic value. It is concluded that immunocytochemistry using a carefully selected panel of monoclonal antibodies is a valuable and convenient means of making an objective distinction between anaplastic thyroid tumours of epithelial or lymphoid origin. IMAGES: Nature Publishing Group 1985-08 /pmc/articles/PMC1977107/ /pubmed/3896289 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ralfkiaer, N.
Gatter, K. C.
Alcock, C.
Heryet, A.
Ralfkiaer, E.
Mason, D. Y.
The value of immunocytochemical methods in the differential diagnosis of anaplastic thyroid tumours.
title The value of immunocytochemical methods in the differential diagnosis of anaplastic thyroid tumours.
title_full The value of immunocytochemical methods in the differential diagnosis of anaplastic thyroid tumours.
title_fullStr The value of immunocytochemical methods in the differential diagnosis of anaplastic thyroid tumours.
title_full_unstemmed The value of immunocytochemical methods in the differential diagnosis of anaplastic thyroid tumours.
title_short The value of immunocytochemical methods in the differential diagnosis of anaplastic thyroid tumours.
title_sort value of immunocytochemical methods in the differential diagnosis of anaplastic thyroid tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977107/
https://www.ncbi.nlm.nih.gov/pubmed/3896289
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