Reevaluation of alkaline phosphatase measurement during Hodgkin's disease by electrophoretic isoenzyme separation.

Electrophoretic isoenzyme separation provides much more precise information than measurement of alkaline phosphatases (AP). Use of this technique for 83 patients with Hodgkin's disease revealed that the presence of the alpha 1 fraction (alpha 1 AP) was very significantly correlated with the sta...

Descripción completa

Detalles Bibliográficos
Autores principales: Thyss, A., Schneider, M., Caldani, C., Viot, M., Bourry, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977111/
https://www.ncbi.nlm.nih.gov/pubmed/4027161
_version_ 1782135192683544576
author Thyss, A.
Schneider, M.
Caldani, C.
Viot, M.
Bourry, J.
author_facet Thyss, A.
Schneider, M.
Caldani, C.
Viot, M.
Bourry, J.
author_sort Thyss, A.
collection PubMed
description Electrophoretic isoenzyme separation provides much more precise information than measurement of alkaline phosphatases (AP). Use of this technique for 83 patients with Hodgkin's disease revealed that the presence of the alpha 1 fraction (alpha 1 AP) was very significantly correlated with the stage of disease extension (P less than 0.01) and above all with the presence of general symptoms (P less than 0.001). Repeat measurements performed during patient follow-up demonstrated a close association between presence of alpha 1 AP and existence of progressive disease. While the mechanism of appearance of this abnormal alpha 1 AP fraction is not linked to Hodgkin-specific liver lesions, this test provides much more interesting data than classical measurement of total alkaline phosphatases (TAP).
format Text
id pubmed-1977111
institution National Center for Biotechnology Information
language English
publishDate 1985
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19771112009-09-10 Reevaluation of alkaline phosphatase measurement during Hodgkin's disease by electrophoretic isoenzyme separation. Thyss, A. Schneider, M. Caldani, C. Viot, M. Bourry, J. Br J Cancer Research Article Electrophoretic isoenzyme separation provides much more precise information than measurement of alkaline phosphatases (AP). Use of this technique for 83 patients with Hodgkin's disease revealed that the presence of the alpha 1 fraction (alpha 1 AP) was very significantly correlated with the stage of disease extension (P less than 0.01) and above all with the presence of general symptoms (P less than 0.001). Repeat measurements performed during patient follow-up demonstrated a close association between presence of alpha 1 AP and existence of progressive disease. While the mechanism of appearance of this abnormal alpha 1 AP fraction is not linked to Hodgkin-specific liver lesions, this test provides much more interesting data than classical measurement of total alkaline phosphatases (TAP). Nature Publishing Group 1985-08 /pmc/articles/PMC1977111/ /pubmed/4027161 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Thyss, A.
Schneider, M.
Caldani, C.
Viot, M.
Bourry, J.
Reevaluation of alkaline phosphatase measurement during Hodgkin's disease by electrophoretic isoenzyme separation.
title Reevaluation of alkaline phosphatase measurement during Hodgkin's disease by electrophoretic isoenzyme separation.
title_full Reevaluation of alkaline phosphatase measurement during Hodgkin's disease by electrophoretic isoenzyme separation.
title_fullStr Reevaluation of alkaline phosphatase measurement during Hodgkin's disease by electrophoretic isoenzyme separation.
title_full_unstemmed Reevaluation of alkaline phosphatase measurement during Hodgkin's disease by electrophoretic isoenzyme separation.
title_short Reevaluation of alkaline phosphatase measurement during Hodgkin's disease by electrophoretic isoenzyme separation.
title_sort reevaluation of alkaline phosphatase measurement during hodgkin's disease by electrophoretic isoenzyme separation.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977111/
https://www.ncbi.nlm.nih.gov/pubmed/4027161
work_keys_str_mv AT thyssa reevaluationofalkalinephosphatasemeasurementduringhodgkinsdiseasebyelectrophoreticisoenzymeseparation
AT schneiderm reevaluationofalkalinephosphatasemeasurementduringhodgkinsdiseasebyelectrophoreticisoenzymeseparation
AT caldanic reevaluationofalkalinephosphatasemeasurementduringhodgkinsdiseasebyelectrophoreticisoenzymeseparation
AT viotm reevaluationofalkalinephosphatasemeasurementduringhodgkinsdiseasebyelectrophoreticisoenzymeseparation
AT bourryj reevaluationofalkalinephosphatasemeasurementduringhodgkinsdiseasebyelectrophoreticisoenzymeseparation

Ejemplares similares