Bleomycin and misonidazole cytotoxicity.

Chinese hamster ovary (CHO) cells were exposed in vitro to combinations of bleomycin and misonidazole under hypoxic conditions. Only one drug was present at any given time and cells were washed before being exposed to the second drug. Both drugs induced potentially lethal damage (PLD). This damage w...

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Autores principales: Korbelik, M., Palcic, B., Skarsgard, L. D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977142/
https://www.ncbi.nlm.nih.gov/pubmed/2579666
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author Korbelik, M.
Palcic, B.
Skarsgard, L. D.
author_facet Korbelik, M.
Palcic, B.
Skarsgard, L. D.
author_sort Korbelik, M.
collection PubMed
description Chinese hamster ovary (CHO) cells were exposed in vitro to combinations of bleomycin and misonidazole under hypoxic conditions. Only one drug was present at any given time and cells were washed before being exposed to the second drug. Both drugs induced potentially lethal damage (PLD). This damage was repaired under hypoxic conditions very rapidly, and bleomycin-induced PLD was repaired more rapidly than misonidazole-induced PLD. If, after the combined treatment, cells are kept in hypoxia, much of the damage can be repaired.
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spelling pubmed-19771422009-09-10 Bleomycin and misonidazole cytotoxicity. Korbelik, M. Palcic, B. Skarsgard, L. D. Br J Cancer Research Article Chinese hamster ovary (CHO) cells were exposed in vitro to combinations of bleomycin and misonidazole under hypoxic conditions. Only one drug was present at any given time and cells were washed before being exposed to the second drug. Both drugs induced potentially lethal damage (PLD). This damage was repaired under hypoxic conditions very rapidly, and bleomycin-induced PLD was repaired more rapidly than misonidazole-induced PLD. If, after the combined treatment, cells are kept in hypoxia, much of the damage can be repaired. Nature Publishing Group 1985-04 /pmc/articles/PMC1977142/ /pubmed/2579666 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Korbelik, M.
Palcic, B.
Skarsgard, L. D.
Bleomycin and misonidazole cytotoxicity.
title Bleomycin and misonidazole cytotoxicity.
title_full Bleomycin and misonidazole cytotoxicity.
title_fullStr Bleomycin and misonidazole cytotoxicity.
title_full_unstemmed Bleomycin and misonidazole cytotoxicity.
title_short Bleomycin and misonidazole cytotoxicity.
title_sort bleomycin and misonidazole cytotoxicity.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977142/
https://www.ncbi.nlm.nih.gov/pubmed/2579666
work_keys_str_mv AT korbelikm bleomycinandmisonidazolecytotoxicity
AT palcicb bleomycinandmisonidazolecytotoxicity
AT skarsgardld bleomycinandmisonidazolecytotoxicity

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