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Advanced seminoma: treatment with cis-platinum-based combination chemotherapy or carboplatin (JM8).
Between 1978 and 1983, 44 patients with advanced seminoma were treated with cis-platinum-based combination chemotherapy (39 patients) or with carboplatin (JM8), as a single agent (5 patients). Of the total group, 40 (90%) are alive and disease free. Two of the 4 patients who died relapsed as non-sem...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1985
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977156/ https://www.ncbi.nlm.nih.gov/pubmed/3893507 |
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author | Peckham, M. J. Horwich, A. Hendry, W. F. |
author_facet | Peckham, M. J. Horwich, A. Hendry, W. F. |
author_sort | Peckham, M. J. |
collection | PubMed |
description | Between 1978 and 1983, 44 patients with advanced seminoma were treated with cis-platinum-based combination chemotherapy (39 patients) or with carboplatin (JM8), as a single agent (5 patients). Of the total group, 40 (90%) are alive and disease free. Two of the 4 patients who died relapsed as non-seminomatous germ-cell tumours. Results in previously untreated patients indicate that tumour volume is less important as a prognostic factor than in non-seminomas. Residual masses were present in almost 80% of patients 1 month after chemotherapy; such masses regress slowly and surgery is not indicated. Elective radiotherapy after chemotherapy appears to be inessential since relapse rates are comparable in irradiated (1/15) and unirradiated patients (1/16). Pretreatment serum HCG concentrations did not influence the outcome of chemotherapy. Preliminary results with JM8 suggest that it is an active single agent in the treatment of seminoma. |
format | Text |
id | pubmed-1977156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1985 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-19771562009-09-10 Advanced seminoma: treatment with cis-platinum-based combination chemotherapy or carboplatin (JM8). Peckham, M. J. Horwich, A. Hendry, W. F. Br J Cancer Research Article Between 1978 and 1983, 44 patients with advanced seminoma were treated with cis-platinum-based combination chemotherapy (39 patients) or with carboplatin (JM8), as a single agent (5 patients). Of the total group, 40 (90%) are alive and disease free. Two of the 4 patients who died relapsed as non-seminomatous germ-cell tumours. Results in previously untreated patients indicate that tumour volume is less important as a prognostic factor than in non-seminomas. Residual masses were present in almost 80% of patients 1 month after chemotherapy; such masses regress slowly and surgery is not indicated. Elective radiotherapy after chemotherapy appears to be inessential since relapse rates are comparable in irradiated (1/15) and unirradiated patients (1/16). Pretreatment serum HCG concentrations did not influence the outcome of chemotherapy. Preliminary results with JM8 suggest that it is an active single agent in the treatment of seminoma. Nature Publishing Group 1985-07 /pmc/articles/PMC1977156/ /pubmed/3893507 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Peckham, M. J. Horwich, A. Hendry, W. F. Advanced seminoma: treatment with cis-platinum-based combination chemotherapy or carboplatin (JM8). |
title | Advanced seminoma: treatment with cis-platinum-based combination chemotherapy or carboplatin (JM8). |
title_full | Advanced seminoma: treatment with cis-platinum-based combination chemotherapy or carboplatin (JM8). |
title_fullStr | Advanced seminoma: treatment with cis-platinum-based combination chemotherapy or carboplatin (JM8). |
title_full_unstemmed | Advanced seminoma: treatment with cis-platinum-based combination chemotherapy or carboplatin (JM8). |
title_short | Advanced seminoma: treatment with cis-platinum-based combination chemotherapy or carboplatin (JM8). |
title_sort | advanced seminoma: treatment with cis-platinum-based combination chemotherapy or carboplatin (jm8). |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977156/ https://www.ncbi.nlm.nih.gov/pubmed/3893507 |
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