The effects of alpha and gamma interferons on human lung cancer cells grown in vitro or as xenografts in nude mice.

We have compared the effects of alpha and recombinant gamma interferons (IFNs) on the growth of human lung cancer cell lines in vitro. There was a diversity of response amongst the lines studied, the most sensitive being COR-L23 (a large cell anaplastic carcinoma line) and POC (a small cell line). I...

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Detalles Bibliográficos
Autores principales: Twentyman, P. R., Workman, P., Wright, K. A., Bleehen, N. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977166/
https://www.ncbi.nlm.nih.gov/pubmed/3925974
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author Twentyman, P. R.
Workman, P.
Wright, K. A.
Bleehen, N. M.
author_facet Twentyman, P. R.
Workman, P.
Wright, K. A.
Bleehen, N. M.
author_sort Twentyman, P. R.
collection PubMed
description We have compared the effects of alpha and recombinant gamma interferons (IFNs) on the growth of human lung cancer cell lines in vitro. There was a diversity of response amongst the lines studied, the most sensitive being COR-L23 (a large cell anaplastic carcinoma line) and POC (a small cell line). In these two lines, IFN-gamma was found to be more potent than IFN-alpha. During cell growth of line POC in the presence of IFN-gamma no significant shift in cell cycle distribution occurred. When lines COR-L23 and POC were grown as xenograft tumours in nude mice, daily injection of 4 X 10(5) units per mouse per day of IFN-gamma produced no discernible retardation of tumour growth.
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spelling pubmed-19771662009-09-10 The effects of alpha and gamma interferons on human lung cancer cells grown in vitro or as xenografts in nude mice. Twentyman, P. R. Workman, P. Wright, K. A. Bleehen, N. M. Br J Cancer Research Article We have compared the effects of alpha and recombinant gamma interferons (IFNs) on the growth of human lung cancer cell lines in vitro. There was a diversity of response amongst the lines studied, the most sensitive being COR-L23 (a large cell anaplastic carcinoma line) and POC (a small cell line). In these two lines, IFN-gamma was found to be more potent than IFN-alpha. During cell growth of line POC in the presence of IFN-gamma no significant shift in cell cycle distribution occurred. When lines COR-L23 and POC were grown as xenograft tumours in nude mice, daily injection of 4 X 10(5) units per mouse per day of IFN-gamma produced no discernible retardation of tumour growth. Nature Publishing Group 1985-07 /pmc/articles/PMC1977166/ /pubmed/3925974 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Twentyman, P. R.
Workman, P.
Wright, K. A.
Bleehen, N. M.
The effects of alpha and gamma interferons on human lung cancer cells grown in vitro or as xenografts in nude mice.
title The effects of alpha and gamma interferons on human lung cancer cells grown in vitro or as xenografts in nude mice.
title_full The effects of alpha and gamma interferons on human lung cancer cells grown in vitro or as xenografts in nude mice.
title_fullStr The effects of alpha and gamma interferons on human lung cancer cells grown in vitro or as xenografts in nude mice.
title_full_unstemmed The effects of alpha and gamma interferons on human lung cancer cells grown in vitro or as xenografts in nude mice.
title_short The effects of alpha and gamma interferons on human lung cancer cells grown in vitro or as xenografts in nude mice.
title_sort effects of alpha and gamma interferons on human lung cancer cells grown in vitro or as xenografts in nude mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977166/
https://www.ncbi.nlm.nih.gov/pubmed/3925974
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