Effective inhibition by low dose aminoglutethimide of peripheral aromatization in postmenopausal breast cancer patients.

Aminoglutethimide without glucocorticoid has been shown to be a clinically effective treatment for postmenopausal breast cancer in low dosage (250 mg day-1). The mechanism of action of this approach is thought to be the inhibition of peripheral aromatase, the enzyme which converts androstenedione to...

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Autores principales: Dowsett, M., Santner, S. J., Santen, R. J., Jeffcoate, S. L., Smith, I. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977168/
https://www.ncbi.nlm.nih.gov/pubmed/4015950
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author Dowsett, M.
Santner, S. J.
Santen, R. J.
Jeffcoate, S. L.
Smith, I. E.
author_facet Dowsett, M.
Santner, S. J.
Santen, R. J.
Jeffcoate, S. L.
Smith, I. E.
author_sort Dowsett, M.
collection PubMed
description Aminoglutethimide without glucocorticoid has been shown to be a clinically effective treatment for postmenopausal breast cancer in low dosage (250 mg day-1). The mechanism of action of this approach is thought to be the inhibition of peripheral aromatase, the enzyme which converts androstenedione to oestrone. The activity of this enzyme was measured in vivo by injection with 3H-androstenedione and 14C-oestrone and found to be 0.20% +/- 0.05 in 5 patients on low dose AG therapy. In comparison with previously published data this demonstrates a 92% inhibition of peripheral aromatase activity confirming aromatase inhibition as a viable aim in the endocrine treatment of breast cancer.
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spelling pubmed-19771682009-09-10 Effective inhibition by low dose aminoglutethimide of peripheral aromatization in postmenopausal breast cancer patients. Dowsett, M. Santner, S. J. Santen, R. J. Jeffcoate, S. L. Smith, I. E. Br J Cancer Research Article Aminoglutethimide without glucocorticoid has been shown to be a clinically effective treatment for postmenopausal breast cancer in low dosage (250 mg day-1). The mechanism of action of this approach is thought to be the inhibition of peripheral aromatase, the enzyme which converts androstenedione to oestrone. The activity of this enzyme was measured in vivo by injection with 3H-androstenedione and 14C-oestrone and found to be 0.20% +/- 0.05 in 5 patients on low dose AG therapy. In comparison with previously published data this demonstrates a 92% inhibition of peripheral aromatase activity confirming aromatase inhibition as a viable aim in the endocrine treatment of breast cancer. Nature Publishing Group 1985-07 /pmc/articles/PMC1977168/ /pubmed/4015950 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Dowsett, M.
Santner, S. J.
Santen, R. J.
Jeffcoate, S. L.
Smith, I. E.
Effective inhibition by low dose aminoglutethimide of peripheral aromatization in postmenopausal breast cancer patients.
title Effective inhibition by low dose aminoglutethimide of peripheral aromatization in postmenopausal breast cancer patients.
title_full Effective inhibition by low dose aminoglutethimide of peripheral aromatization in postmenopausal breast cancer patients.
title_fullStr Effective inhibition by low dose aminoglutethimide of peripheral aromatization in postmenopausal breast cancer patients.
title_full_unstemmed Effective inhibition by low dose aminoglutethimide of peripheral aromatization in postmenopausal breast cancer patients.
title_short Effective inhibition by low dose aminoglutethimide of peripheral aromatization in postmenopausal breast cancer patients.
title_sort effective inhibition by low dose aminoglutethimide of peripheral aromatization in postmenopausal breast cancer patients.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977168/
https://www.ncbi.nlm.nih.gov/pubmed/4015950
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