Detection of placental-type alkaline phosphatase in ovarian cancer.

A monoclonal antibody, H317, has been used for the sensitive and specific detection of placental-type alkaline phosphatase (PLAP) in sera, solubilized tissue extracts and fixed tumour tissue sections from patients representing a variety of ovarian tumours. PLAP was detected in over 30% of these sera...

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Autores principales: McDicken, I. W., McLaughlin, P. J., Tromans, P. M., Luesley, D. M., Johnson, P. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977171/
https://www.ncbi.nlm.nih.gov/pubmed/3893506
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author McDicken, I. W.
McLaughlin, P. J.
Tromans, P. M.
Luesley, D. M.
Johnson, P. M.
author_facet McDicken, I. W.
McLaughlin, P. J.
Tromans, P. M.
Luesley, D. M.
Johnson, P. M.
author_sort McDicken, I. W.
collection PubMed
description A monoclonal antibody, H317, has been used for the sensitive and specific detection of placental-type alkaline phosphatase (PLAP) in sera, solubilized tissue extracts and fixed tumour tissue sections from patients representing a variety of ovarian tumours. PLAP was detected in over 30% of these sera and in most solubilized tumour tissue extracts. There was no association between circulating PLAP levels and either tissue extract levels or immunohistological staining of ovarian tumour tissue sections with H317. Nevertheless, immunohistology demonstrated the heterogeneity of cellular localization of PLAP within different tumours, and can often be of value in localizing tumour tissue. IMAGES:
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spelling pubmed-19771712009-09-10 Detection of placental-type alkaline phosphatase in ovarian cancer. McDicken, I. W. McLaughlin, P. J. Tromans, P. M. Luesley, D. M. Johnson, P. M. Br J Cancer Research Article A monoclonal antibody, H317, has been used for the sensitive and specific detection of placental-type alkaline phosphatase (PLAP) in sera, solubilized tissue extracts and fixed tumour tissue sections from patients representing a variety of ovarian tumours. PLAP was detected in over 30% of these sera and in most solubilized tumour tissue extracts. There was no association between circulating PLAP levels and either tissue extract levels or immunohistological staining of ovarian tumour tissue sections with H317. Nevertheless, immunohistology demonstrated the heterogeneity of cellular localization of PLAP within different tumours, and can often be of value in localizing tumour tissue. IMAGES: Nature Publishing Group 1985-07 /pmc/articles/PMC1977171/ /pubmed/3893506 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
McDicken, I. W.
McLaughlin, P. J.
Tromans, P. M.
Luesley, D. M.
Johnson, P. M.
Detection of placental-type alkaline phosphatase in ovarian cancer.
title Detection of placental-type alkaline phosphatase in ovarian cancer.
title_full Detection of placental-type alkaline phosphatase in ovarian cancer.
title_fullStr Detection of placental-type alkaline phosphatase in ovarian cancer.
title_full_unstemmed Detection of placental-type alkaline phosphatase in ovarian cancer.
title_short Detection of placental-type alkaline phosphatase in ovarian cancer.
title_sort detection of placental-type alkaline phosphatase in ovarian cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977171/
https://www.ncbi.nlm.nih.gov/pubmed/3893506
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AT luesleydm detectionofplacentaltypealkalinephosphataseinovariancancer
AT johnsonpm detectionofplacentaltypealkalinephosphataseinovariancancer

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