Incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (APL).

Cytogenetic analysis was carried out on peripheral blood cultures from seven patients with acute promyelocytic leukaemia (APL-M3). A reciprocal 15;17 chromosome translocation, t(15q+;17q-), was found in all cases, and the breakpoints estimated to be 15q22 and 17q12-21. In addition to the t(15q+;17q-...

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Autores principales: Sheer, D., Lister, T. A., Amess, J., Solomon, E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977183/
https://www.ncbi.nlm.nih.gov/pubmed/3860247
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author Sheer, D.
Lister, T. A.
Amess, J.
Solomon, E.
author_facet Sheer, D.
Lister, T. A.
Amess, J.
Solomon, E.
author_sort Sheer, D.
collection PubMed
description Cytogenetic analysis was carried out on peripheral blood cultures from seven patients with acute promyelocytic leukaemia (APL-M3). A reciprocal 15;17 chromosome translocation, t(15q+;17q-), was found in all cases, and the breakpoints estimated to be 15q22 and 17q12-21. In addition to the t(15q+;17q-), trisomy 10 was found in 50% of cells analysed in one case. These results suggest that the 15;17 chromosome translocation may be observed in most cases of APL where the leukaemic cells are cultured before cytogenetic analysis is performed. The use of conditioned media in the culture of leukaemic cells is also described. IMAGES:
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spelling pubmed-19771832009-09-10 Incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (APL). Sheer, D. Lister, T. A. Amess, J. Solomon, E. Br J Cancer Research Article Cytogenetic analysis was carried out on peripheral blood cultures from seven patients with acute promyelocytic leukaemia (APL-M3). A reciprocal 15;17 chromosome translocation, t(15q+;17q-), was found in all cases, and the breakpoints estimated to be 15q22 and 17q12-21. In addition to the t(15q+;17q-), trisomy 10 was found in 50% of cells analysed in one case. These results suggest that the 15;17 chromosome translocation may be observed in most cases of APL where the leukaemic cells are cultured before cytogenetic analysis is performed. The use of conditioned media in the culture of leukaemic cells is also described. IMAGES: Nature Publishing Group 1985-07 /pmc/articles/PMC1977183/ /pubmed/3860247 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Sheer, D.
Lister, T. A.
Amess, J.
Solomon, E.
Incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (APL).
title Incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (APL).
title_full Incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (APL).
title_fullStr Incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (APL).
title_full_unstemmed Incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (APL).
title_short Incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (APL).
title_sort incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (apl).
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977183/
https://www.ncbi.nlm.nih.gov/pubmed/3860247
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