Cytotoxicity of etretinate and vindesine.

The effects of an aromatic retinoid, etretinate and a vinca alkaloid, vindesine were investigated by culture of malignant melanoma cells in vitro with these two agents; either separately or in combination. Etretinate inhibited growth of a murine melanoma but only minimal effects were recorded with t...

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Autores principales: Gaukroger, J. M., Wilson, L., MacKie, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977201/
https://www.ncbi.nlm.nih.gov/pubmed/4041363
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author Gaukroger, J. M.
Wilson, L.
MacKie, R.
author_facet Gaukroger, J. M.
Wilson, L.
MacKie, R.
author_sort Gaukroger, J. M.
collection PubMed
description The effects of an aromatic retinoid, etretinate and a vinca alkaloid, vindesine were investigated by culture of malignant melanoma cells in vitro with these two agents; either separately or in combination. Etretinate inhibited growth of a murine melanoma but only minimal effects were recorded with two human melanomas. Vindesine however, was inhibitory for all of the cell lines and this effect was enhanced in the presence of the retinoid. Entry of 3H labelled vindesine or etretinate into drug free cells was followed in the absence or presence of unlabelled drug. It was found that etretinate enhanced cellular uptake of vindesine in two of the cell lines and this may be responsible for the enhanced toxicity of vindesine in the presence of etretinate. The human melanoma which did not exhibit retinoid stimulated vindesine uptake, appeared to be intrinsically sensitive to the vinca alkaloid. No effect on cellular retinoid uptake by vindesine was recorded in any of the melanomas. The results indicate that the intracellular concentrations combined with the intrinsic sensitivities of each cell line to etretinate and vindesine determines the toxic response.
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spelling pubmed-19772012009-09-10 Cytotoxicity of etretinate and vindesine. Gaukroger, J. M. Wilson, L. MacKie, R. Br J Cancer Research Article The effects of an aromatic retinoid, etretinate and a vinca alkaloid, vindesine were investigated by culture of malignant melanoma cells in vitro with these two agents; either separately or in combination. Etretinate inhibited growth of a murine melanoma but only minimal effects were recorded with two human melanomas. Vindesine however, was inhibitory for all of the cell lines and this effect was enhanced in the presence of the retinoid. Entry of 3H labelled vindesine or etretinate into drug free cells was followed in the absence or presence of unlabelled drug. It was found that etretinate enhanced cellular uptake of vindesine in two of the cell lines and this may be responsible for the enhanced toxicity of vindesine in the presence of etretinate. The human melanoma which did not exhibit retinoid stimulated vindesine uptake, appeared to be intrinsically sensitive to the vinca alkaloid. No effect on cellular retinoid uptake by vindesine was recorded in any of the melanomas. The results indicate that the intracellular concentrations combined with the intrinsic sensitivities of each cell line to etretinate and vindesine determines the toxic response. Nature Publishing Group 1985-09 /pmc/articles/PMC1977201/ /pubmed/4041363 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Gaukroger, J. M.
Wilson, L.
MacKie, R.
Cytotoxicity of etretinate and vindesine.
title Cytotoxicity of etretinate and vindesine.
title_full Cytotoxicity of etretinate and vindesine.
title_fullStr Cytotoxicity of etretinate and vindesine.
title_full_unstemmed Cytotoxicity of etretinate and vindesine.
title_short Cytotoxicity of etretinate and vindesine.
title_sort cytotoxicity of etretinate and vindesine.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977201/
https://www.ncbi.nlm.nih.gov/pubmed/4041363
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