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Three months treatment with chemotherapy and radiotherapy for small cell lung cancer.

Fifty-five patients with inoperable but limited stage small cell carcinoma of the bronchus and a further 15 patients with contra lateral neck nodes, pleural effusions and marrow involvement were entered into the study and treated. The 3 month treatment regimen comprised 3 courses of etoposide with c...

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Autores principales: Thatcher, N., Stout, R., Smith, D. B., Grötte, G., Winson, M., Bassett, H., Carroll, K. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977208/
https://www.ncbi.nlm.nih.gov/pubmed/2994703
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author Thatcher, N.
Stout, R.
Smith, D. B.
Grötte, G.
Winson, M.
Bassett, H.
Carroll, K. B.
author_facet Thatcher, N.
Stout, R.
Smith, D. B.
Grötte, G.
Winson, M.
Bassett, H.
Carroll, K. B.
author_sort Thatcher, N.
collection PubMed
description Fifty-five patients with inoperable but limited stage small cell carcinoma of the bronchus and a further 15 patients with contra lateral neck nodes, pleural effusions and marrow involvement were entered into the study and treated. The 3 month treatment regimen comprised 3 courses of etoposide with cyclophosphamide at 2.5 gm-2 followed by methotrexate and radiotherapy, no maintenance treatment was given. The complete response rate in the total patient group was 54% and the partial response rate 21%. The median survival was 11 months for the 70 patients, 15 months for the complete responders, and those patients with a bronchoscopically confirmed complete response survived significantly longer. There was no significant difference between the patients with strictly limited stage disease and those in the broader category. Eight patients are tumour free and alive one year or more after the end of treatment. The median followup is 17 months. Twenty-four patients were delayed 1-2 weeks during treatment because of chemotherapy induced toxicity. Six patients died probably of infection associated with leucopaenia. The majority of the patients' Karnofsky performance improved with the treatment as did their breathlessness assessed on a respiratory score. The short intensive chemotherapy regimen of 3 months produced similar results to those following more prolonged treatment regimens.
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spelling pubmed-19772082009-09-10 Three months treatment with chemotherapy and radiotherapy for small cell lung cancer. Thatcher, N. Stout, R. Smith, D. B. Grötte, G. Winson, M. Bassett, H. Carroll, K. B. Br J Cancer Research Article Fifty-five patients with inoperable but limited stage small cell carcinoma of the bronchus and a further 15 patients with contra lateral neck nodes, pleural effusions and marrow involvement were entered into the study and treated. The 3 month treatment regimen comprised 3 courses of etoposide with cyclophosphamide at 2.5 gm-2 followed by methotrexate and radiotherapy, no maintenance treatment was given. The complete response rate in the total patient group was 54% and the partial response rate 21%. The median survival was 11 months for the 70 patients, 15 months for the complete responders, and those patients with a bronchoscopically confirmed complete response survived significantly longer. There was no significant difference between the patients with strictly limited stage disease and those in the broader category. Eight patients are tumour free and alive one year or more after the end of treatment. The median followup is 17 months. Twenty-four patients were delayed 1-2 weeks during treatment because of chemotherapy induced toxicity. Six patients died probably of infection associated with leucopaenia. The majority of the patients' Karnofsky performance improved with the treatment as did their breathlessness assessed on a respiratory score. The short intensive chemotherapy regimen of 3 months produced similar results to those following more prolonged treatment regimens. Nature Publishing Group 1985-09 /pmc/articles/PMC1977208/ /pubmed/2994703 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Thatcher, N.
Stout, R.
Smith, D. B.
Grötte, G.
Winson, M.
Bassett, H.
Carroll, K. B.
Three months treatment with chemotherapy and radiotherapy for small cell lung cancer.
title Three months treatment with chemotherapy and radiotherapy for small cell lung cancer.
title_full Three months treatment with chemotherapy and radiotherapy for small cell lung cancer.
title_fullStr Three months treatment with chemotherapy and radiotherapy for small cell lung cancer.
title_full_unstemmed Three months treatment with chemotherapy and radiotherapy for small cell lung cancer.
title_short Three months treatment with chemotherapy and radiotherapy for small cell lung cancer.
title_sort three months treatment with chemotherapy and radiotherapy for small cell lung cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977208/
https://www.ncbi.nlm.nih.gov/pubmed/2994703
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