Urinary pseudouridine excretion in myelomatosis.

Urinary psi excretion is independent of the main indices of tumour activity in myelomatosis (serum paraprotein, serum beta 2-microglobulin, serum creatinine and urinary light chain production). The mean (+/- s.d.) psi at presentation was 40.7 +/- 22.6 nmol. mumol ucr-1, compared to 25.4 +/- 4.8 nmol...

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Autores principales: Sørensen, S. H., Brown, D. A., Cooper, E. H., Kelly, K. A., MacLennan, I. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1985
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977279/
https://www.ncbi.nlm.nih.gov/pubmed/3907686
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author Sørensen, S. H.
Brown, D. A.
Cooper, E. H.
Kelly, K. A.
MacLennan, I. C.
author_facet Sørensen, S. H.
Brown, D. A.
Cooper, E. H.
Kelly, K. A.
MacLennan, I. C.
author_sort Sørensen, S. H.
collection PubMed
description Urinary psi excretion is independent of the main indices of tumour activity in myelomatosis (serum paraprotein, serum beta 2-microglobulin, serum creatinine and urinary light chain production). The mean (+/- s.d.) psi at presentation was 40.7 +/- 22.6 nmol. mumol ucr-1, compared to 25.4 +/- 4.8 nmol. mumol ucr-1 in controls. Urinary psi levels at presentation are significantly related to prognosis, the higher the level the poorer the prognosis. However, when these levels have been stratified according to the corresponding level of serum beta 2m, the level adds little as a prognostic factor.
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spelling pubmed-19772792009-09-10 Urinary pseudouridine excretion in myelomatosis. Sørensen, S. H. Brown, D. A. Cooper, E. H. Kelly, K. A. MacLennan, I. C. Br J Cancer Research Article Urinary psi excretion is independent of the main indices of tumour activity in myelomatosis (serum paraprotein, serum beta 2-microglobulin, serum creatinine and urinary light chain production). The mean (+/- s.d.) psi at presentation was 40.7 +/- 22.6 nmol. mumol ucr-1, compared to 25.4 +/- 4.8 nmol. mumol ucr-1 in controls. Urinary psi levels at presentation are significantly related to prognosis, the higher the level the poorer the prognosis. However, when these levels have been stratified according to the corresponding level of serum beta 2m, the level adds little as a prognostic factor. Nature Publishing Group 1985-12 /pmc/articles/PMC1977279/ /pubmed/3907686 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Sørensen, S. H.
Brown, D. A.
Cooper, E. H.
Kelly, K. A.
MacLennan, I. C.
Urinary pseudouridine excretion in myelomatosis.
title Urinary pseudouridine excretion in myelomatosis.
title_full Urinary pseudouridine excretion in myelomatosis.
title_fullStr Urinary pseudouridine excretion in myelomatosis.
title_full_unstemmed Urinary pseudouridine excretion in myelomatosis.
title_short Urinary pseudouridine excretion in myelomatosis.
title_sort urinary pseudouridine excretion in myelomatosis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977279/
https://www.ncbi.nlm.nih.gov/pubmed/3907686
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