Multiple epitopes of the human ovarian cancer antigen 14C1 recognised by human IgG antibodies: their potential in immunotherapy.

We have defined a novel ovarian cancer-associated membrane antigen, 14C1, using human monoclonal antibodies derived by EBV-transformation of in situ sensitised patients' B-cells. The pattern of recognition of this antigen by these antibodies suggests that at least three epitopes are discernable...

Descripción completa

Detalles Bibliográficos
Autores principales: Gallagher, G., al-Azzawi, F., Walsh, L. P., Wilson, G., Handley, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977296/
https://www.ncbi.nlm.nih.gov/pubmed/1713052
_version_ 1782135231366561792
author Gallagher, G.
al-Azzawi, F.
Walsh, L. P.
Wilson, G.
Handley, J.
author_facet Gallagher, G.
al-Azzawi, F.
Walsh, L. P.
Wilson, G.
Handley, J.
author_sort Gallagher, G.
collection PubMed
description We have defined a novel ovarian cancer-associated membrane antigen, 14C1, using human monoclonal antibodies derived by EBV-transformation of in situ sensitised patients' B-cells. The pattern of recognition of this antigen by these antibodies suggests that at least three epitopes are discernable. These antibodies can be used to promote the in vitro killing of ovarian cancer cells by activated macrophages and cytokines, implying a role for this antigen in the immunotherapy of ovarian malignancies. Evidence is presented that the 14C1 antigen may have some transmembrane signalling function. IMAGES:
format Text
id pubmed-1977296
institution National Center for Biotechnology Information
language English
publishDate 1991
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19772962009-09-10 Multiple epitopes of the human ovarian cancer antigen 14C1 recognised by human IgG antibodies: their potential in immunotherapy. Gallagher, G. al-Azzawi, F. Walsh, L. P. Wilson, G. Handley, J. Br J Cancer Research Article We have defined a novel ovarian cancer-associated membrane antigen, 14C1, using human monoclonal antibodies derived by EBV-transformation of in situ sensitised patients' B-cells. The pattern of recognition of this antigen by these antibodies suggests that at least three epitopes are discernable. These antibodies can be used to promote the in vitro killing of ovarian cancer cells by activated macrophages and cytokines, implying a role for this antigen in the immunotherapy of ovarian malignancies. Evidence is presented that the 14C1 antigen may have some transmembrane signalling function. IMAGES: Nature Publishing Group 1991-07 /pmc/articles/PMC1977296/ /pubmed/1713052 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Gallagher, G.
al-Azzawi, F.
Walsh, L. P.
Wilson, G.
Handley, J.
Multiple epitopes of the human ovarian cancer antigen 14C1 recognised by human IgG antibodies: their potential in immunotherapy.
title Multiple epitopes of the human ovarian cancer antigen 14C1 recognised by human IgG antibodies: their potential in immunotherapy.
title_full Multiple epitopes of the human ovarian cancer antigen 14C1 recognised by human IgG antibodies: their potential in immunotherapy.
title_fullStr Multiple epitopes of the human ovarian cancer antigen 14C1 recognised by human IgG antibodies: their potential in immunotherapy.
title_full_unstemmed Multiple epitopes of the human ovarian cancer antigen 14C1 recognised by human IgG antibodies: their potential in immunotherapy.
title_short Multiple epitopes of the human ovarian cancer antigen 14C1 recognised by human IgG antibodies: their potential in immunotherapy.
title_sort multiple epitopes of the human ovarian cancer antigen 14c1 recognised by human igg antibodies: their potential in immunotherapy.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977296/
https://www.ncbi.nlm.nih.gov/pubmed/1713052
work_keys_str_mv AT gallagherg multipleepitopesofthehumanovariancancerantigen14c1recognisedbyhumaniggantibodiestheirpotentialinimmunotherapy
AT alazzawif multipleepitopesofthehumanovariancancerantigen14c1recognisedbyhumaniggantibodiestheirpotentialinimmunotherapy
AT walshlp multipleepitopesofthehumanovariancancerantigen14c1recognisedbyhumaniggantibodiestheirpotentialinimmunotherapy
AT wilsong multipleepitopesofthehumanovariancancerantigen14c1recognisedbyhumaniggantibodiestheirpotentialinimmunotherapy
AT handleyj multipleepitopesofthehumanovariancancerantigen14c1recognisedbyhumaniggantibodiestheirpotentialinimmunotherapy

Ejemplares similares