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Laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in Victoria, Australia.

Clinical factors were studied in a population based survey of 1,116 cases of testicular neoplasms in Victoria, Australia, between 1950 and 1978. The ratio of right to left sided tumours was 54:46, but the left side predominated among sarcomas (P = 0.006), and in older men. The relative risk (RR) for...

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Autores principales: Stone, J. M., Cruickshank, D. G., Sandeman, T. F., Matthews, J. P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977325/
https://www.ncbi.nlm.nih.gov/pubmed/1677257
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author Stone, J. M.
Cruickshank, D. G.
Sandeman, T. F.
Matthews, J. P.
author_facet Stone, J. M.
Cruickshank, D. G.
Sandeman, T. F.
Matthews, J. P.
author_sort Stone, J. M.
collection PubMed
description Clinical factors were studied in a population based survey of 1,116 cases of testicular neoplasms in Victoria, Australia, between 1950 and 1978. The ratio of right to left sided tumours was 54:46, but the left side predominated among sarcomas (P = 0.006), and in older men. The relative risk (RR) for men with unilateral maldescent was 15 (CI 10-23) and for men with bilateral maldescent 33 (CI 20-55) (odds ratio 1.4, CI 0.5-4, P = 0.7). Calculations per testis in men with unilateral maldescent showed an elevated risk for both the maldescended testis (RR 28, CI 19-41, P less than 0.0001) and the normally descended testis (RR 3, CI 1.2-6, P = 0.04). The RR for men with abdominal maldescent was 55 (CI 36-83) compared to 7 (CI 4-11) for those with inguinal maldescent (odds ratio 8, CI 3-20, P less than 0.0001). Seminomas were more common than nonseminomas (NSGCT) in men with a history of maldescent (odds ratio 1.7, CI 1.1-3, P = 0.02) and also among corrected cryptorchids compared to uncorrected (P = 0.005). Seminomas were diagnosed at an earlier median age in men with corrected cryptorchid testes compared to uncorrected (P = 0.03) and in men with corrected cryptorchid testes compared to normally descended (P = 0.001). Maldescent was also associated with hernia (P = 0.04). Twenty-eight per cent of patients recorded a history of trauma with a higher proportion among NSGCT than among seminomas (P = 0.03). Prior malignancies were reported in nine patients, compared to 3.6 expected; prostate cancer (2) and malignant melanoma (2) were the greatest contributors to the excess.
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spelling pubmed-19773252009-09-10 Laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in Victoria, Australia. Stone, J. M. Cruickshank, D. G. Sandeman, T. F. Matthews, J. P. Br J Cancer Research Article Clinical factors were studied in a population based survey of 1,116 cases of testicular neoplasms in Victoria, Australia, between 1950 and 1978. The ratio of right to left sided tumours was 54:46, but the left side predominated among sarcomas (P = 0.006), and in older men. The relative risk (RR) for men with unilateral maldescent was 15 (CI 10-23) and for men with bilateral maldescent 33 (CI 20-55) (odds ratio 1.4, CI 0.5-4, P = 0.7). Calculations per testis in men with unilateral maldescent showed an elevated risk for both the maldescended testis (RR 28, CI 19-41, P less than 0.0001) and the normally descended testis (RR 3, CI 1.2-6, P = 0.04). The RR for men with abdominal maldescent was 55 (CI 36-83) compared to 7 (CI 4-11) for those with inguinal maldescent (odds ratio 8, CI 3-20, P less than 0.0001). Seminomas were more common than nonseminomas (NSGCT) in men with a history of maldescent (odds ratio 1.7, CI 1.1-3, P = 0.02) and also among corrected cryptorchids compared to uncorrected (P = 0.005). Seminomas were diagnosed at an earlier median age in men with corrected cryptorchid testes compared to uncorrected (P = 0.03) and in men with corrected cryptorchid testes compared to normally descended (P = 0.001). Maldescent was also associated with hernia (P = 0.04). Twenty-eight per cent of patients recorded a history of trauma with a higher proportion among NSGCT than among seminomas (P = 0.03). Prior malignancies were reported in nine patients, compared to 3.6 expected; prostate cancer (2) and malignant melanoma (2) were the greatest contributors to the excess. Nature Publishing Group 1991-07 /pmc/articles/PMC1977325/ /pubmed/1677257 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Stone, J. M.
Cruickshank, D. G.
Sandeman, T. F.
Matthews, J. P.
Laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in Victoria, Australia.
title Laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in Victoria, Australia.
title_full Laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in Victoria, Australia.
title_fullStr Laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in Victoria, Australia.
title_full_unstemmed Laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in Victoria, Australia.
title_short Laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in Victoria, Australia.
title_sort laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in victoria, australia.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977325/
https://www.ncbi.nlm.nih.gov/pubmed/1677257
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