Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide.

The radiolabelled opioid receptor binding affinities of morphine and its active metabolite morphine 6-glucuronide at the total mu, mu 1, mu 2 and delta receptors were determined. Morphine 6-glucuronide was found to have a 4-fold lower affinity for the mu 2 receptor (IC50 17 nM and 82 nM for morphine...

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Detalles Bibliográficos
Autores principales: Hucks, D., Thompson, P. I., McLoughlin, L., Joel, S. P., Patel, N., Grossman, A., Rees, L. H., Slevin, M. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977344/
https://www.ncbi.nlm.nih.gov/pubmed/1310249

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