Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma.

Conflicting results have been published on the prognostic significance of t(14;18) in follicular lymphoma: Yunis et al. (1989) reported that its presence indicated poor response to therapy and short survival, whereas Levine et al. (1988) showed no difference in prognosis between cases with and witho...

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Autores principales: Pezzella, F., Jones, M., Ralfkiaer, E., Ersbøll, J., Gatter, K. C., Mason, D. Y.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977367/
https://www.ncbi.nlm.nih.gov/pubmed/1733447
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author Pezzella, F.
Jones, M.
Ralfkiaer, E.
Ersbøll, J.
Gatter, K. C.
Mason, D. Y.
author_facet Pezzella, F.
Jones, M.
Ralfkiaer, E.
Ersbøll, J.
Gatter, K. C.
Mason, D. Y.
author_sort Pezzella, F.
collection PubMed
description Conflicting results have been published on the prognostic significance of t(14;18) in follicular lymphoma: Yunis et al. (1989) reported that its presence indicated poor response to therapy and short survival, whereas Levine et al. (1988) showed no difference in prognosis between cases with and without the translocation. However these results were based on small series of cases and on follow-up periods (no longer than 7 years) which are relatively short for a disease with such a slow clinical evolution. Here we report an investigation of 70 cases of follicular lymphoma with long term follow-up data (up to 17 years). This series has been studied for the presence of the 14;18 translocation and for the expression of bcl-2 protein. Our results show that there are no grounds for considering either the 14;18 translocation or the expression of the bcl-2 protein to be useful prognostic markers in clinical practice.
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spelling pubmed-19773672009-09-10 Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma. Pezzella, F. Jones, M. Ralfkiaer, E. Ersbøll, J. Gatter, K. C. Mason, D. Y. Br J Cancer Research Article Conflicting results have been published on the prognostic significance of t(14;18) in follicular lymphoma: Yunis et al. (1989) reported that its presence indicated poor response to therapy and short survival, whereas Levine et al. (1988) showed no difference in prognosis between cases with and without the translocation. However these results were based on small series of cases and on follow-up periods (no longer than 7 years) which are relatively short for a disease with such a slow clinical evolution. Here we report an investigation of 70 cases of follicular lymphoma with long term follow-up data (up to 17 years). This series has been studied for the presence of the 14;18 translocation and for the expression of bcl-2 protein. Our results show that there are no grounds for considering either the 14;18 translocation or the expression of the bcl-2 protein to be useful prognostic markers in clinical practice. Nature Publishing Group 1992-01 /pmc/articles/PMC1977367/ /pubmed/1733447 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Pezzella, F.
Jones, M.
Ralfkiaer, E.
Ersbøll, J.
Gatter, K. C.
Mason, D. Y.
Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma.
title Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma.
title_full Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma.
title_fullStr Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma.
title_full_unstemmed Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma.
title_short Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma.
title_sort evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977367/
https://www.ncbi.nlm.nih.gov/pubmed/1733447
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