P53 mutations in gastric carcinomas.

We carried out an immunohistochemical study and DNA analysis of 30 gastric carcinomas to evaluate p53 overexpression and allelic loss at 17p. The immunohistochemical study demonstrated immunoreactivity for p53 protein in four cases. Allelic loss for the pYNZ22.1 marker was detected in nine cases. In...

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Autores principales: Seruca, R., David, L., Holm, R., Nesland, J. M., Fangan, B. M., Castedo, S., Sobrinho-Simões, M., Børresen, A. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977375/
https://www.ncbi.nlm.nih.gov/pubmed/1586599
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author Seruca, R.
David, L.
Holm, R.
Nesland, J. M.
Fangan, B. M.
Castedo, S.
Sobrinho-Simões, M.
Børresen, A. L.
author_facet Seruca, R.
David, L.
Holm, R.
Nesland, J. M.
Fangan, B. M.
Castedo, S.
Sobrinho-Simões, M.
Børresen, A. L.
author_sort Seruca, R.
collection PubMed
description We carried out an immunohistochemical study and DNA analysis of 30 gastric carcinomas to evaluate p53 overexpression and allelic loss at 17p. The immunohistochemical study demonstrated immunoreactivity for p53 protein in four cases. Allelic loss for the pYNZ22.1 marker was detected in nine cases. In total, ten cases showed immunoreactivity for p53 protein, allelic loss, or both. The study of nine of these cases by constant denaturant gel electrophoresis revealed p53 mutations in three cases. We conclude that the prevalence of mutations of p53 in our series is similar to what has recently been observed in other cases of gastric cancer, but lower than in colon carcinomas. IMAGES:
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spelling pubmed-19773752009-09-10 P53 mutations in gastric carcinomas. Seruca, R. David, L. Holm, R. Nesland, J. M. Fangan, B. M. Castedo, S. Sobrinho-Simões, M. Børresen, A. L. Br J Cancer Research Article We carried out an immunohistochemical study and DNA analysis of 30 gastric carcinomas to evaluate p53 overexpression and allelic loss at 17p. The immunohistochemical study demonstrated immunoreactivity for p53 protein in four cases. Allelic loss for the pYNZ22.1 marker was detected in nine cases. In total, ten cases showed immunoreactivity for p53 protein, allelic loss, or both. The study of nine of these cases by constant denaturant gel electrophoresis revealed p53 mutations in three cases. We conclude that the prevalence of mutations of p53 in our series is similar to what has recently been observed in other cases of gastric cancer, but lower than in colon carcinomas. IMAGES: Nature Publishing Group 1992-05 /pmc/articles/PMC1977375/ /pubmed/1586599 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Seruca, R.
David, L.
Holm, R.
Nesland, J. M.
Fangan, B. M.
Castedo, S.
Sobrinho-Simões, M.
Børresen, A. L.
P53 mutations in gastric carcinomas.
title P53 mutations in gastric carcinomas.
title_full P53 mutations in gastric carcinomas.
title_fullStr P53 mutations in gastric carcinomas.
title_full_unstemmed P53 mutations in gastric carcinomas.
title_short P53 mutations in gastric carcinomas.
title_sort p53 mutations in gastric carcinomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977375/
https://www.ncbi.nlm.nih.gov/pubmed/1586599
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