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Interleukin-4 receptor and epidermal growth factor receptor expression in colorectal cancer.

Interleukin-4 receptor (IL-4R) and Epidermal Growth Factor receptor (EGFR) were assessed as factors associated with adenoma-carcinoma progression in colorectal cancer and tumour invasion. A monoclonal antibody (MR6) was applied to detect IL-4R in: metaplastic polyps (five cases), adenomas (15 cases)...

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Autores principales: Kaklamanis, L., Gatter, K. C., Mortensen, N., Harris, A. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977405/
https://www.ncbi.nlm.nih.gov/pubmed/1419612
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author Kaklamanis, L.
Gatter, K. C.
Mortensen, N.
Harris, A. L.
author_facet Kaklamanis, L.
Gatter, K. C.
Mortensen, N.
Harris, A. L.
author_sort Kaklamanis, L.
collection PubMed
description Interleukin-4 receptor (IL-4R) and Epidermal Growth Factor receptor (EGFR) were assessed as factors associated with adenoma-carcinoma progression in colorectal cancer and tumour invasion. A monoclonal antibody (MR6) was applied to detect IL-4R in: metaplastic polyps (five cases), adenomas (15 cases), and carcinomas (44 adenocarcinomas and one squamous cell). Positive labelling was obtained in all polyps, adenomas and in 40/45 carcinomas. Normal colonic mucosa of these patients, as well as macrophages and lymphocytes infiltrating the tumour stroma, were also positively labelled with MR6. Four out of five poorly differentiated adenocarcinomas did not show IL-4 receptor expression. No significant correlation was found with tumour size, lymph node stage and IL-4 receptor expression. On the above specimens a parallel detection of epidermal growth factor receptors (EGFR) by a monoclonal antibody (EGFR 1) was carried out. Expression of EGFR was found in 14/20 polyps and in 22/45 carcinomas. All but one of the EGFR positive malignant tumours showed coexpression of IL-4 receptor. Lymph node involvement by tumour cells was detected in 25 out of 45 patients. Eighteen of these 25 cases were positive with EGFR1. IMAGES:
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spelling pubmed-19774052009-09-10 Interleukin-4 receptor and epidermal growth factor receptor expression in colorectal cancer. Kaklamanis, L. Gatter, K. C. Mortensen, N. Harris, A. L. Br J Cancer Research Article Interleukin-4 receptor (IL-4R) and Epidermal Growth Factor receptor (EGFR) were assessed as factors associated with adenoma-carcinoma progression in colorectal cancer and tumour invasion. A monoclonal antibody (MR6) was applied to detect IL-4R in: metaplastic polyps (five cases), adenomas (15 cases), and carcinomas (44 adenocarcinomas and one squamous cell). Positive labelling was obtained in all polyps, adenomas and in 40/45 carcinomas. Normal colonic mucosa of these patients, as well as macrophages and lymphocytes infiltrating the tumour stroma, were also positively labelled with MR6. Four out of five poorly differentiated adenocarcinomas did not show IL-4 receptor expression. No significant correlation was found with tumour size, lymph node stage and IL-4 receptor expression. On the above specimens a parallel detection of epidermal growth factor receptors (EGFR) by a monoclonal antibody (EGFR 1) was carried out. Expression of EGFR was found in 14/20 polyps and in 22/45 carcinomas. All but one of the EGFR positive malignant tumours showed coexpression of IL-4 receptor. Lymph node involvement by tumour cells was detected in 25 out of 45 patients. Eighteen of these 25 cases were positive with EGFR1. IMAGES: Nature Publishing Group 1992-10 /pmc/articles/PMC1977405/ /pubmed/1419612 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Kaklamanis, L.
Gatter, K. C.
Mortensen, N.
Harris, A. L.
Interleukin-4 receptor and epidermal growth factor receptor expression in colorectal cancer.
title Interleukin-4 receptor and epidermal growth factor receptor expression in colorectal cancer.
title_full Interleukin-4 receptor and epidermal growth factor receptor expression in colorectal cancer.
title_fullStr Interleukin-4 receptor and epidermal growth factor receptor expression in colorectal cancer.
title_full_unstemmed Interleukin-4 receptor and epidermal growth factor receptor expression in colorectal cancer.
title_short Interleukin-4 receptor and epidermal growth factor receptor expression in colorectal cancer.
title_sort interleukin-4 receptor and epidermal growth factor receptor expression in colorectal cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977405/
https://www.ncbi.nlm.nih.gov/pubmed/1419612
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