p53 expression in Reed-Sternberg cells of Hodgkin's disease.

Mutation of the p53 protein may represent the commonest genetic event in human malignancy. Abnormal p53 expression has been reported in a variety of carcinomas, sarcomas and lymphoid neoplasms; however there is little information in relation to Hodgkin's disease. The expression of the nuclear p...

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Autores principales: Gupta, R. K., Norton, A. J., Thompson, I. W., Lister, T. A., Bodmer, J. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977425/
https://www.ncbi.nlm.nih.gov/pubmed/1419601
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author Gupta, R. K.
Norton, A. J.
Thompson, I. W.
Lister, T. A.
Bodmer, J. G.
author_facet Gupta, R. K.
Norton, A. J.
Thompson, I. W.
Lister, T. A.
Bodmer, J. G.
author_sort Gupta, R. K.
collection PubMed
description Mutation of the p53 protein may represent the commonest genetic event in human malignancy. Abnormal p53 expression has been reported in a variety of carcinomas, sarcomas and lymphoid neoplasms; however there is little information in relation to Hodgkin's disease. The expression of the nuclear phosphoprotein was investigated in paraffin-embedded biopsies from fifty patients with Hodgkin's disease using a polyclonal antibody, CM-1 and in snap-frozen material with monoclonal antibodies, PAb 1801 and PAb 240. Specifically, immunoreactivity was localised to the Reed-Sternberg cells or mononuclear variants in both nodular sclerosing (86% cases) and mixed cellularity (57% cases) subtypes of Hodgkin's disease. However, no positive staining was found in our cases of nodular lymphocyte predominant type Hodgkin's disease. Serial biopsies following recurrence of disease demonstrated consistent results. It is suggested that overexpression of p53, probably mutant, may have a role in the tumorigenesis of Hodgkin's disease. IMAGES:
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spelling pubmed-19774252009-09-10 p53 expression in Reed-Sternberg cells of Hodgkin's disease. Gupta, R. K. Norton, A. J. Thompson, I. W. Lister, T. A. Bodmer, J. G. Br J Cancer Research Article Mutation of the p53 protein may represent the commonest genetic event in human malignancy. Abnormal p53 expression has been reported in a variety of carcinomas, sarcomas and lymphoid neoplasms; however there is little information in relation to Hodgkin's disease. The expression of the nuclear phosphoprotein was investigated in paraffin-embedded biopsies from fifty patients with Hodgkin's disease using a polyclonal antibody, CM-1 and in snap-frozen material with monoclonal antibodies, PAb 1801 and PAb 240. Specifically, immunoreactivity was localised to the Reed-Sternberg cells or mononuclear variants in both nodular sclerosing (86% cases) and mixed cellularity (57% cases) subtypes of Hodgkin's disease. However, no positive staining was found in our cases of nodular lymphocyte predominant type Hodgkin's disease. Serial biopsies following recurrence of disease demonstrated consistent results. It is suggested that overexpression of p53, probably mutant, may have a role in the tumorigenesis of Hodgkin's disease. IMAGES: Nature Publishing Group 1992-10 /pmc/articles/PMC1977425/ /pubmed/1419601 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Gupta, R. K.
Norton, A. J.
Thompson, I. W.
Lister, T. A.
Bodmer, J. G.
p53 expression in Reed-Sternberg cells of Hodgkin's disease.
title p53 expression in Reed-Sternberg cells of Hodgkin's disease.
title_full p53 expression in Reed-Sternberg cells of Hodgkin's disease.
title_fullStr p53 expression in Reed-Sternberg cells of Hodgkin's disease.
title_full_unstemmed p53 expression in Reed-Sternberg cells of Hodgkin's disease.
title_short p53 expression in Reed-Sternberg cells of Hodgkin's disease.
title_sort p53 expression in reed-sternberg cells of hodgkin's disease.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977425/
https://www.ncbi.nlm.nih.gov/pubmed/1419601
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