Cargando…

The effect of circulating antigen and radiolabel stability on the biodistribution of an indium labelled antibody.

This study has investigated two of the main problems with radiolabelled antibody imaging, the formation of circulating immune complexes (I.C.) and the non specific binding of radiolabel to the antibody molecule. Patients undergoing immunoscintigraphy with 111In labelled monoclonal antibody ICR2 were...

Descripción completa

Detalles Bibliográficos
Autores principales:	Davidson, B. R., Babich, J., Young, H., Waddington, W., Clarke, G., Short, M., Boulos, P., Styles, J., Dean, C.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1991
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977445/ https://www.ncbi.nlm.nih.gov/pubmed/1931605

Ejemplares similares

Radiolabelling of Antigen and Liposomes for Vaccine Biodistribution Studies
por: Henriksen-Lacey, Malou, et al.
Publicado: (2010)

Biodistribution of a Radiolabeled Antibody in Mice as an Approach to Evaluating Antibody Pharmacokinetics
por: Allen, Kevin J. H., et al.
Publicado: (2018)

Radiolabeling of Cramoll 1,4: Evaluation of the Biodistribution
por: Ferreira de Carvalho Patricio, Beatriz, et al.
Publicado: (2011)

Comparative biodistributions of indium-111-labelled macrocycle chimeric B72.3 antibody conjugates in tumour-bearing mice.
por: Turner, A., et al.
Publicado: (1994)

TrisOxine abiotic siderophores for technetium complexation: radiolabeling and biodistribution studies
por: Leenhardt, Julien, et al.
Publicado: (2023)

Biodistribution of (68/67)Ga-Radiolabeled Sphingolipid Nanoemulsions by PET and SPECT Imaging
por: Díez-Villares, Sandra, et al.
Publicado: (2021)

Humanization, Radiolabeling and Biodistribution Studies of an IgG(1)-Type Antibody Targeting Uncomplexed PSA for Theranostic Applications
por: Strand, Joanna, et al.
Publicado: (2021)

Epitope Blocking: Positive and Negative Effects on the Biodistribution of (125)I‐Labeled Anti‐Tac Disulfide‐stabilized Fv Fragment of Two Antibodies against Different Epitopes of the Circulating Antigen
por: Kobayashi, Hisataka, et al.
Publicado: (1998)

Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats
por: Priyadarshani, Anjali, et al.
Publicado: (2010)

Physiologically Based Pharmacokinetic (PBPK) Model for Biodistribution of Radiolabeled Peptides in Patients with Neuroendocrine Tumours
por: Gospavic, Radovan, et al.
Publicado: (2016)

(124)I Radiolabeling of a Au(III)‐NHC Complex for In Vivo Biodistribution Studies
por: Guarra, Federica, et al.
Publicado: (2020)

PSMA as a target for radiolabelled small molecules
por: Eder, Matthias, et al.
Publicado: (2013)

Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice
por: Vegt, Erik, et al.
Publicado: (2010)

In vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope
por: Collingridge, D R, et al.
Publicado: (2003)

Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach
por: Faruqu, Farid N., et al.
Publicado: (2019)

Organ Biodistribution of Radiolabelled γδ T Cells Following Liposomal Alendronate Administration in Different Mouse Tumour Models
por: Wang, Julie T-W., et al.
Publicado: (2020)

Biodistribution of Mesoporous Carbon Nanoparticles via Technetium-99m Radiolabelling after Oral Administration to Mice
por: Mamai, Maria, et al.
Publicado: (2021)

Imaging of Recurrent Intestinal Carcinoma with Indium‐lll‐labeled Anti‐carcinoembryonic Antigen Monoclonal Antibody CEA102
por: Nakada, Kazuhiko, et al.
Publicado: (1997)

In vivo biodistribution and toxicology studies of cadmium-free indium-based quantum dot nanoparticles in a rat model
por: Yaghini, Elnaz, et al.
Publicado: (2018)

2,3-Dihydro-1H-cyclopenta[b]quinoline Derivatives as Acetylcholinesterase Inhibitors—Synthesis, Radiolabeling and Biodistribution
por: Szymański, Paweł, et al.
Publicado: (2012)

Nanotamoxifen Delivery System: Toxicity Assessment After Oral Administration and Biodistribution Study After Intravenous Delivery of Radiolabeled Nanotamoxifen
por: Shukla, Jaya, et al.
Publicado: (2016)

Engineering Intrinsically Zirconium‐89 Radiolabeled Self‐Destructing Mesoporous Silica Nanostructures for In Vivo Biodistribution and Tumor Targeting Studies
por: Goel, Shreya, et al.
Publicado: (2016)

Radiolabelled polymeric IgA: from biodistribution to a new molecular imaging tool in colorectal cancer lung metastases
por: Carpenet, Helene, et al.
Publicado: (2017)

Cyanopyridinone- and Cyanopyridine-Based Cancer Cell Pim-1 Inhibitors: Design, Synthesis, Radiolabeling, Biodistribution, and Molecular Modeling Simulation
por: Mansour, Basem, et al.
Publicado: (2023)

Anti-glycoprotein antibodies and sequestration pattern of indium-labeled platelets in immune thrombocytopenia
por: Amini, Sufia N., et al.
Publicado: (2022)

Biodistribution of a radiolabelled monoclonal antibody NY3D11 recognizing the neural cell adhesion molecule in tumour xenografts and patients with small-cell lung cancer.
por: Ornadel, D., et al.
Publicado: (1998)

Sodium-22-radiolabeled silica nanoparticles as new radiotracer for biomedical applications: in vivo positron emission tomography imaging, biodistribution, and biocompatibility
por: Al Faraj, Achraf, et al.
Publicado: (2015)

Brain targeting of zolmitriptan via transdermal terpesomes: statistical optimization and in vivo biodistribution study by (99m)Tc radiolabeling technique
por: Tawfik, Mai Ahmed, et al.
Publicado: (2023)

Immunoscintigraphy of small-cell lung cancer: a study using technetium and indium labelled anti-carcinoembryonic antigen monoclonal antibody preparations.
por: Macmillan, C. H., et al.
Publicado: (1993)

Ra‐224 labeling of calcium carbonate microparticles for internal α‐therapy: Preparation, stability, and biodistribution in mice
por: Westrøm, Sara, et al.
Publicado: (2018)

Biodistribution of (99m)Tc Labeled Integrin Antagonist
por: Jang, Beom-Su, et al.
Publicado: (2013)

Radiolabeled Peptides and Antibodies in Medicine
por: Kręcisz, Paweł, et al.
Publicado: (2020)

Radiolabeled antibodies in renal cell carcinoma
por: Stillebroer, Alexander B., et al.
Publicado: (2007)

J$/\psi$ production in indium-indium collisions
por: Arnaldi, R, et al.
Publicado: (2005)

Radioimmunotherapy of metastatic colorectal tumours with iodine-131-labelled antibody to carcinoembryonic antigen: phase I/II study with comparative biodistribution of intact and F(ab')2 antibodies.
por: Lane, D. M., et al.
Publicado: (1994)

Biodistribution and radiation dosimetry of (11)C-labelled docetaxel in cancer patients
por: van der Veldt, Astrid A. M., et al.
Publicado: (2010)

Immune activity and biodistribution of polypeptide K237 and folic acid conjugated amphiphilic PEG-PLGA copolymer nanoparticles radiolabeled with (99m)Tc
por: He, Zelai, et al.
Publicado: (2016)

In vitro and in vivo studies of an aqueous extract of Matricaria recutita (German chamomile) on the radiolabeling of blood constituents, on the morphology of red blood cells and on the biodistribution of the radiopharmaceutical sodium pertechnetate
por: Garcia-Pinto, Angélica B., et al.
Publicado: (2013)

Effect of intratumoral administration on biodistribution of (64)Cu-labeled nanoshells
por: Xie, Huan, et al.
Publicado: (2012)

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles
por: Álamo, Patricia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_obe9mkk48349q7gvtaec463bqv