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Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein.

Resistance to multiple antitumour drugs, mostly antibiotics or alkaloids, has been associated with a cellular plasma membrane P-glycoprotein (Pgp), causing energy-dependent transport of drugs out of cells. However, in many common chemotherapy resistant human cancers there is no overexpression of Pgp...

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Detalles Bibliográficos
Autores principales:	Schuurhuis, G. J., Broxterman, H. J., de Lange, J. H., Pinedo, H. M., van Heijningen, T. H., Kuiper, C. M., Scheffer, G. L., Scheper, R. J., van Kalken, C. K., Baak, J. P.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1991
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977458/ https://www.ncbi.nlm.nih.gov/pubmed/1681887

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