Thyroid dysfunction can predict response to immunotherapy with interleukin-2 and interferon-2 alpha.

Thyroid dysfunction is a well-recognised side-effect of treatment with interleukin-2 (IL2). We assessed the correlation between the development of abnormal thyroid function and tumour response in 13 patients receiving IL2 and interferon-2 alpha (IFN2 alpha) for advanced malignancy. Seven patients ha...

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Detalles Bibliográficos
Autores principales: Reid, I., Sharpe, I., McDevitt, J., Maxwell, W., Emmons, R., Tanner, W. A., Monson, J. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977462/
https://www.ncbi.nlm.nih.gov/pubmed/1931616
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author Reid, I.
Sharpe, I.
McDevitt, J.
Maxwell, W.
Emmons, R.
Tanner, W. A.
Monson, J. R.
author_facet Reid, I.
Sharpe, I.
McDevitt, J.
Maxwell, W.
Emmons, R.
Tanner, W. A.
Monson, J. R.
author_sort Reid, I.
collection PubMed
description Thyroid dysfunction is a well-recognised side-effect of treatment with interleukin-2 (IL2). We assessed the correlation between the development of abnormal thyroid function and tumour response in 13 patients receiving IL2 and interferon-2 alpha (IFN2 alpha) for advanced malignancy. Seven patients had normal thyroid function during treatment, and all of these patients have since died of progressive disease. Of six patients who did develop thyroid dysfunction during treatment, one patient has died of progressive disease. However, statistically we were unable to confirm a definite correlation between the development of thyroid dysfunction and survival in this small group of patients.
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spelling pubmed-19774622009-09-10 Thyroid dysfunction can predict response to immunotherapy with interleukin-2 and interferon-2 alpha. Reid, I. Sharpe, I. McDevitt, J. Maxwell, W. Emmons, R. Tanner, W. A. Monson, J. R. Br J Cancer Research Article Thyroid dysfunction is a well-recognised side-effect of treatment with interleukin-2 (IL2). We assessed the correlation between the development of abnormal thyroid function and tumour response in 13 patients receiving IL2 and interferon-2 alpha (IFN2 alpha) for advanced malignancy. Seven patients had normal thyroid function during treatment, and all of these patients have since died of progressive disease. Of six patients who did develop thyroid dysfunction during treatment, one patient has died of progressive disease. However, statistically we were unable to confirm a definite correlation between the development of thyroid dysfunction and survival in this small group of patients. Nature Publishing Group 1991-11 /pmc/articles/PMC1977462/ /pubmed/1931616 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Reid, I.
Sharpe, I.
McDevitt, J.
Maxwell, W.
Emmons, R.
Tanner, W. A.
Monson, J. R.
Thyroid dysfunction can predict response to immunotherapy with interleukin-2 and interferon-2 alpha.
title Thyroid dysfunction can predict response to immunotherapy with interleukin-2 and interferon-2 alpha.
title_full Thyroid dysfunction can predict response to immunotherapy with interleukin-2 and interferon-2 alpha.
title_fullStr Thyroid dysfunction can predict response to immunotherapy with interleukin-2 and interferon-2 alpha.
title_full_unstemmed Thyroid dysfunction can predict response to immunotherapy with interleukin-2 and interferon-2 alpha.
title_short Thyroid dysfunction can predict response to immunotherapy with interleukin-2 and interferon-2 alpha.
title_sort thyroid dysfunction can predict response to immunotherapy with interleukin-2 and interferon-2 alpha.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977462/
https://www.ncbi.nlm.nih.gov/pubmed/1931616
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