Regional chemotherapy for inoperable renal carcinoma: a method of targeting therapeutic microspheres to tumour.

Regionally-administered, drug-loaded microspheres have a potential role in the treatment of renal tumours. Vasoactive agents, for example, angiotensin II, may allow selective delivery of microspheres to tumour. The present study defines the regional advantage that may be obtained from angiotensin II...

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Autores principales: Anderson, J. H., Willmott, N., Bessent, R., Angerson, W. J., Kerr, D. J., McArdle, C. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977499/
https://www.ncbi.nlm.nih.gov/pubmed/1892766
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author Anderson, J. H.
Willmott, N.
Bessent, R.
Angerson, W. J.
Kerr, D. J.
McArdle, C. S.
author_facet Anderson, J. H.
Willmott, N.
Bessent, R.
Angerson, W. J.
Kerr, D. J.
McArdle, C. S.
author_sort Anderson, J. H.
collection PubMed
description Regionally-administered, drug-loaded microspheres have a potential role in the treatment of renal tumours. Vasoactive agents, for example, angiotensin II, may allow selective delivery of microspheres to tumour. The present study defines the regional advantage that may be obtained from angiotensin II by quantifying tumour and normal kidney blood flow using radiolabelled microsphere renal perfusion studies and per-operative laser-doppler flow measurements. Angiotensin II increased microsphere distribution to tumour, relative to normal kidney, by a factor of four. This enhancement was associated with an absolute increase in tumour blood flow. IMAGES:
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spelling pubmed-19774992009-09-10 Regional chemotherapy for inoperable renal carcinoma: a method of targeting therapeutic microspheres to tumour. Anderson, J. H. Willmott, N. Bessent, R. Angerson, W. J. Kerr, D. J. McArdle, C. S. Br J Cancer Research Article Regionally-administered, drug-loaded microspheres have a potential role in the treatment of renal tumours. Vasoactive agents, for example, angiotensin II, may allow selective delivery of microspheres to tumour. The present study defines the regional advantage that may be obtained from angiotensin II by quantifying tumour and normal kidney blood flow using radiolabelled microsphere renal perfusion studies and per-operative laser-doppler flow measurements. Angiotensin II increased microsphere distribution to tumour, relative to normal kidney, by a factor of four. This enhancement was associated with an absolute increase in tumour blood flow. IMAGES: Nature Publishing Group 1991-08 /pmc/articles/PMC1977499/ /pubmed/1892766 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Anderson, J. H.
Willmott, N.
Bessent, R.
Angerson, W. J.
Kerr, D. J.
McArdle, C. S.
Regional chemotherapy for inoperable renal carcinoma: a method of targeting therapeutic microspheres to tumour.
title Regional chemotherapy for inoperable renal carcinoma: a method of targeting therapeutic microspheres to tumour.
title_full Regional chemotherapy for inoperable renal carcinoma: a method of targeting therapeutic microspheres to tumour.
title_fullStr Regional chemotherapy for inoperable renal carcinoma: a method of targeting therapeutic microspheres to tumour.
title_full_unstemmed Regional chemotherapy for inoperable renal carcinoma: a method of targeting therapeutic microspheres to tumour.
title_short Regional chemotherapy for inoperable renal carcinoma: a method of targeting therapeutic microspheres to tumour.
title_sort regional chemotherapy for inoperable renal carcinoma: a method of targeting therapeutic microspheres to tumour.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977499/
https://www.ncbi.nlm.nih.gov/pubmed/1892766
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