Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples.

Thirty-five cases of Hodgkin's disease (HD) were analysed for the presence of Epstein-Barr virus (EBV) and human herpesvirus-6 (HHV-6) DNA. EBV genomes were detected in 11/35 cases while none of the cases was positive for HHV-6. Ten of the EBV-positive cases were subsequently analysed using a p...

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Autores principales: Gledhill, S., Gallagher, A., Jones, D. B., Krajewski, A. S., Alexander, F. E., Klee, E., Wright, D. H., O'Brien, C., Onions, D. E., Jarrett, R. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977506/
https://www.ncbi.nlm.nih.gov/pubmed/1654072
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author Gledhill, S.
Gallagher, A.
Jones, D. B.
Krajewski, A. S.
Alexander, F. E.
Klee, E.
Wright, D. H.
O'Brien, C.
Onions, D. E.
Jarrett, R. F.
author_facet Gledhill, S.
Gallagher, A.
Jones, D. B.
Krajewski, A. S.
Alexander, F. E.
Klee, E.
Wright, D. H.
O'Brien, C.
Onions, D. E.
Jarrett, R. F.
author_sort Gledhill, S.
collection PubMed
description Thirty-five cases of Hodgkin's disease (HD) were analysed for the presence of Epstein-Barr virus (EBV) and human herpesvirus-6 (HHV-6) DNA. EBV genomes were detected in 11/35 cases while none of the cases was positive for HHV-6. Ten of the EBV-positive cases were subsequently analysed using a probe for the terminal region of the virus; the results suggested that the EBV-infected cells were clonally expanded. EBV subtypes specific DNA amplification was used to demonstrate that EBV subtype A, and not subtype B was present in the EBV-positive cases. The age distribution of the EBV-positive cases indicated a statistically significant trend for an increase in positivity with increasing age. This is the first indication that EBV is significantly associated with any subset of HD patients. IMAGES:
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spelling pubmed-19775062009-09-10 Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples. Gledhill, S. Gallagher, A. Jones, D. B. Krajewski, A. S. Alexander, F. E. Klee, E. Wright, D. H. O'Brien, C. Onions, D. E. Jarrett, R. F. Br J Cancer Research Article Thirty-five cases of Hodgkin's disease (HD) were analysed for the presence of Epstein-Barr virus (EBV) and human herpesvirus-6 (HHV-6) DNA. EBV genomes were detected in 11/35 cases while none of the cases was positive for HHV-6. Ten of the EBV-positive cases were subsequently analysed using a probe for the terminal region of the virus; the results suggested that the EBV-infected cells were clonally expanded. EBV subtypes specific DNA amplification was used to demonstrate that EBV subtype A, and not subtype B was present in the EBV-positive cases. The age distribution of the EBV-positive cases indicated a statistically significant trend for an increase in positivity with increasing age. This is the first indication that EBV is significantly associated with any subset of HD patients. IMAGES: Nature Publishing Group 1991-08 /pmc/articles/PMC1977506/ /pubmed/1654072 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Gledhill, S.
Gallagher, A.
Jones, D. B.
Krajewski, A. S.
Alexander, F. E.
Klee, E.
Wright, D. H.
O'Brien, C.
Onions, D. E.
Jarrett, R. F.
Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples.
title Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples.
title_full Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples.
title_fullStr Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples.
title_full_unstemmed Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples.
title_short Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples.
title_sort viral involvement in hodgkin's disease: detection of clonal type a epstein-barr virus genomes in tumour samples.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977506/
https://www.ncbi.nlm.nih.gov/pubmed/1654072
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