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The effects of vasopressin infusion on hepatic haemodynamics in an experimental model of liver metastases.
Vasoactive drugs have a variety of effects upon splanchnic and hepatic haemodynamics which may alter tumour blood flow and potentiate the delivery of a chemotherapeutic drug to hepatic tumour. We have investigated the effects of vasopressin infusion on hepatic tumour blood flow in an experimental mo...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1991
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977507/ https://www.ncbi.nlm.nih.gov/pubmed/1892747 |
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author | Hemingway, D. M. Chang, D. Cooke, T. G. Jenkins, S. A. |
author_facet | Hemingway, D. M. Chang, D. Cooke, T. G. Jenkins, S. A. |
author_sort | Hemingway, D. M. |
collection | PubMed |
description | Vasoactive drugs have a variety of effects upon splanchnic and hepatic haemodynamics which may alter tumour blood flow and potentiate the delivery of a chemotherapeutic drug to hepatic tumour. We have investigated the effects of vasopressin infusion on hepatic tumour blood flow in an experimental model of liver tumour. Hepatic tumour was induced by the intraportal inoculation of HSN sarcoma cells. Hepatic and splanchnic blood flow was determined using a dual reference microsphere technique before and after an intravenous infusion of vasopressin at a dose of 0.1 mU kg-1 min-1 for 10 min. There was a significant increase in systemic arterial blood pressure associated with a rise in portal venous inflow (P less than 0.01, Wilcoxen Signed rank Test) and a significant fall in hepatic arterial flow (P less than 0.05). The tumour: liver blood flow ratio was significantly increased by vasopressin infusion (P less than 0.02). Vasopressin infusion decreases hepatic arterial flow and increases tumour blood flow which may potentiate the delivery of a regionally delivered chemotherapeutic drug to hepatic tumour. |
format | Text |
id | pubmed-1977507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1991 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-19775072009-09-10 The effects of vasopressin infusion on hepatic haemodynamics in an experimental model of liver metastases. Hemingway, D. M. Chang, D. Cooke, T. G. Jenkins, S. A. Br J Cancer Research Article Vasoactive drugs have a variety of effects upon splanchnic and hepatic haemodynamics which may alter tumour blood flow and potentiate the delivery of a chemotherapeutic drug to hepatic tumour. We have investigated the effects of vasopressin infusion on hepatic tumour blood flow in an experimental model of liver tumour. Hepatic tumour was induced by the intraportal inoculation of HSN sarcoma cells. Hepatic and splanchnic blood flow was determined using a dual reference microsphere technique before and after an intravenous infusion of vasopressin at a dose of 0.1 mU kg-1 min-1 for 10 min. There was a significant increase in systemic arterial blood pressure associated with a rise in portal venous inflow (P less than 0.01, Wilcoxen Signed rank Test) and a significant fall in hepatic arterial flow (P less than 0.05). The tumour: liver blood flow ratio was significantly increased by vasopressin infusion (P less than 0.02). Vasopressin infusion decreases hepatic arterial flow and increases tumour blood flow which may potentiate the delivery of a regionally delivered chemotherapeutic drug to hepatic tumour. Nature Publishing Group 1991-08 /pmc/articles/PMC1977507/ /pubmed/1892747 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Hemingway, D. M. Chang, D. Cooke, T. G. Jenkins, S. A. The effects of vasopressin infusion on hepatic haemodynamics in an experimental model of liver metastases. |
title | The effects of vasopressin infusion on hepatic haemodynamics in an experimental model of liver metastases. |
title_full | The effects of vasopressin infusion on hepatic haemodynamics in an experimental model of liver metastases. |
title_fullStr | The effects of vasopressin infusion on hepatic haemodynamics in an experimental model of liver metastases. |
title_full_unstemmed | The effects of vasopressin infusion on hepatic haemodynamics in an experimental model of liver metastases. |
title_short | The effects of vasopressin infusion on hepatic haemodynamics in an experimental model of liver metastases. |
title_sort | effects of vasopressin infusion on hepatic haemodynamics in an experimental model of liver metastases. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977507/ https://www.ncbi.nlm.nih.gov/pubmed/1892747 |
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