Hormone control of total plasminogen activator activity is specific to malignant DMBA-induced rat mammary tumours.

Hormonal regulation of plasminogen activator expression in 7,12-dimethylbenz[a]anthracene (DMBA)--induced rat mammary carcinomas was studied both in vivo and in vitro and was compared to that in DMBA-mammary dysplasia induced in neonatally androgenised rats. The plasminogen activator activity in DMB...

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Autores principales: Inada, K., Yamashita, J., Matsuo, S., Nakashima, Y., Yamashita, S., Ogawa, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977557/
https://www.ncbi.nlm.nih.gov/pubmed/1562466
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author Inada, K.
Yamashita, J.
Matsuo, S.
Nakashima, Y.
Yamashita, S.
Ogawa, M.
author_facet Inada, K.
Yamashita, J.
Matsuo, S.
Nakashima, Y.
Yamashita, S.
Ogawa, M.
author_sort Inada, K.
collection PubMed
description Hormonal regulation of plasminogen activator expression in 7,12-dimethylbenz[a]anthracene (DMBA)--induced rat mammary carcinomas was studied both in vivo and in vitro and was compared to that in DMBA-mammary dysplasia induced in neonatally androgenised rats. The plasminogen activator activity in DMBA-mammary carcinomas, but not in DMBA-mammary dysplasia, was regulated by oestrogen. This suggests that expression of this enzyme is hormonally regulated in carcinoma cells. Furthermore, in two of six DMBA-mammary carcinoma groups classified in terms of hormonal treatment, plasminogen activator activity was not under the control of oestrogen. Thus, the present results suggest that at the time of carcinogenesis, the hormonal milieu determines the hormone sensitivities of the malignant cells.
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spelling pubmed-19775572009-09-10 Hormone control of total plasminogen activator activity is specific to malignant DMBA-induced rat mammary tumours. Inada, K. Yamashita, J. Matsuo, S. Nakashima, Y. Yamashita, S. Ogawa, M. Br J Cancer Research Article Hormonal regulation of plasminogen activator expression in 7,12-dimethylbenz[a]anthracene (DMBA)--induced rat mammary carcinomas was studied both in vivo and in vitro and was compared to that in DMBA-mammary dysplasia induced in neonatally androgenised rats. The plasminogen activator activity in DMBA-mammary carcinomas, but not in DMBA-mammary dysplasia, was regulated by oestrogen. This suggests that expression of this enzyme is hormonally regulated in carcinoma cells. Furthermore, in two of six DMBA-mammary carcinoma groups classified in terms of hormonal treatment, plasminogen activator activity was not under the control of oestrogen. Thus, the present results suggest that at the time of carcinogenesis, the hormonal milieu determines the hormone sensitivities of the malignant cells. Nature Publishing Group 1992-04 /pmc/articles/PMC1977557/ /pubmed/1562466 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Inada, K.
Yamashita, J.
Matsuo, S.
Nakashima, Y.
Yamashita, S.
Ogawa, M.
Hormone control of total plasminogen activator activity is specific to malignant DMBA-induced rat mammary tumours.
title Hormone control of total plasminogen activator activity is specific to malignant DMBA-induced rat mammary tumours.
title_full Hormone control of total plasminogen activator activity is specific to malignant DMBA-induced rat mammary tumours.
title_fullStr Hormone control of total plasminogen activator activity is specific to malignant DMBA-induced rat mammary tumours.
title_full_unstemmed Hormone control of total plasminogen activator activity is specific to malignant DMBA-induced rat mammary tumours.
title_short Hormone control of total plasminogen activator activity is specific to malignant DMBA-induced rat mammary tumours.
title_sort hormone control of total plasminogen activator activity is specific to malignant dmba-induced rat mammary tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977557/
https://www.ncbi.nlm.nih.gov/pubmed/1562466
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