c-src structure in human cancers with elevated pp60c-src activity.

We used RNAase protection and restriction fragment length polymorphism assays to detect activating mutations of c-src in a spectrum of human tumours. No mutations were detected at codons 98, 381, 444, and 530. We conclude that mutational activation is not the mechanism of enhancement of pp60c-src-sp...

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Detalles Bibliográficos
Autores principales: Wang, P., Fromowitz, F., Koslow, M., Hagag, N., Johnson, B., Viola, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977675/
https://www.ncbi.nlm.nih.gov/pubmed/1716952
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author Wang, P.
Fromowitz, F.
Koslow, M.
Hagag, N.
Johnson, B.
Viola, M.
author_facet Wang, P.
Fromowitz, F.
Koslow, M.
Hagag, N.
Johnson, B.
Viola, M.
author_sort Wang, P.
collection PubMed
description We used RNAase protection and restriction fragment length polymorphism assays to detect activating mutations of c-src in a spectrum of human tumours. No mutations were detected at codons 98, 381, 444, and 530. We conclude that mutational activation is not the mechanism of enhancement of pp60c-src-specific kinase activity found in a number of human cancer types. IMAGES:
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spelling pubmed-19776752009-09-10 c-src structure in human cancers with elevated pp60c-src activity. Wang, P. Fromowitz, F. Koslow, M. Hagag, N. Johnson, B. Viola, M. Br J Cancer Research Article We used RNAase protection and restriction fragment length polymorphism assays to detect activating mutations of c-src in a spectrum of human tumours. No mutations were detected at codons 98, 381, 444, and 530. We conclude that mutational activation is not the mechanism of enhancement of pp60c-src-specific kinase activity found in a number of human cancer types. IMAGES: Nature Publishing Group 1991-09 /pmc/articles/PMC1977675/ /pubmed/1716952 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Wang, P.
Fromowitz, F.
Koslow, M.
Hagag, N.
Johnson, B.
Viola, M.
c-src structure in human cancers with elevated pp60c-src activity.
title c-src structure in human cancers with elevated pp60c-src activity.
title_full c-src structure in human cancers with elevated pp60c-src activity.
title_fullStr c-src structure in human cancers with elevated pp60c-src activity.
title_full_unstemmed c-src structure in human cancers with elevated pp60c-src activity.
title_short c-src structure in human cancers with elevated pp60c-src activity.
title_sort c-src structure in human cancers with elevated pp60c-src activity.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977675/
https://www.ncbi.nlm.nih.gov/pubmed/1716952
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AT johnsonb csrcstructureinhumancancerswithelevatedpp60csrcactivity
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