Cargando…

The effect of ricin B chain on the intracellular trafficking of an A chain immunotoxin.

Covalent linkage of the A chain of ricin to the LICR-LOND-Fib75 monoclonal antibody produced an immunotoxin, Fib75-SS-ricin A, which demonstrated immunospecific toxicity to human bladder carcinoma cells in tissue culture (Forrester et al., 1984). The present studies have shown that ricin B chain pot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Timar, J., McIntosh, D. P., Henry, R., Cumber, A. J., Parnell, G. D., Davies, A. J.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1991
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977687/ https://www.ncbi.nlm.nih.gov/pubmed/1911213

Ejemplares similares

Cytotoxicity of a cell-reactive immunotoxin containing ricin A chain is potentiated by an anti-immunotoxin containing ricin B chain
Publicado: (1984)

Pharmacokinetic studies in mice with ICI D0490, a novel recombinant ricin A-chain immunotoxin.
por: Calvete, J. A., et al.
Publicado: (1993)

Selective cytotoxic effects of a ricin A chain immunotoxin made with the monoclonal antibody SWA11 recognising a human small cell lung cancer antigen.
por: Wawrzynczak, E. J., et al.
Publicado: (1990)

Molecular and biological properties of an abrin A chain immunotoxin designed for therapy of human small cell lung cancer.
por: Wawrzynczak, E. J., et al.
Publicado: (1992)

Potent cytotoxic action of the immunotoxin SWA11-ricin A chain against human small cell lung cancer cell lines.
por: Derbyshire, E. J., et al.
Publicado: (1992)

In vivo therapy of a murine B cell tumor (BCL1) using antibody-ricin A chain immunotoxins
Publicado: (1982)

Abrin Immunotoxin: Targeted Cytotoxicity and Intracellular Trafficking Pathway
por: Gadadhar, Sudarshan, et al.
Publicado: (2013)

Yeast Reporter Assay to Identify Cellular Components of Ricin Toxin A Chain Trafficking
por: Becker, Björn, et al.
Publicado: (2016)

Ricin Trafficking in Cells
por: Spooner, Robert A., et al.
Publicado: (2015)

Heterogeneous response of individual multicellular tumour spheroids to immunotoxins and ricin toxin.
por: Chignola, R., et al.
Publicado: (1995)

BCMab1-Ra, a novel immunotoxin that BCMab1 antibody coupled to Ricin A chain, can eliminate bladder tumor
por: Li, Chong, et al.
Publicado: (2016)

Ricin Trafficking in Plant and Mammalian Cells
por: Lord, J. Michael, et al.
Publicado: (2011)

Inhibitors of the Cellular Trafficking of Ricin
por: Barbier, Julien, et al.
Publicado: (2012)

Recombinant ricin toxin A chain cytotoxicity against carcinoembryonic antigen expressing tumour cells mediated by a bispecific monoclonal antibody and its potentiation by ricin toxin B chain.
por: Embleton, M. J., et al.
Publicado: (1991)

Temporary inhibition of Moloney-murine sarcoma virus (M-MSV) induced-tumours by adoptive transfer of ricin-treated T-lymphocytes.
por: Cerundolo, V., et al.
Publicado: (1987)

Sites of vulnerability on ricin B chain revealed through epitope mapping of toxin-neutralizing monoclonal antibodies
por: Vance, David J., et al.
Publicado: (2020)

Strong protection against ricin challenge induced by a novel modified ricin A-chain protein in mouse model
por: Zhang, Tao, et al.
Publicado: (2015)

Structural Re-Alignment in an Immunogenic Surface Region of Ricin A Chain
por: Zemla, Adam T., et al.
Publicado: (2008)

Antibody to Ricin A Chain Hinders Intracellular Routing of Toxin and Protects Cells Even after Toxin Has Been Internalized
por: Song, Kejing, et al.
Publicado: (2013)

Adapting Yeast as Model to Study Ricin Toxin A Uptake and Trafficking(‡)
por: Becker, Björn, et al.
Publicado: (2011)

Ricin B Chain Targeted to the Endoplasmic Reticulum of Tobacco Protoplasts Is Degraded by a CDC48- and Vacuole-independent Mechanism
por: Chamberlain, Kerry L., et al.
Publicado: (2008)

Intracellular Transport and Cytotoxicity of the Protein Toxin Ricin
por: Sowa-Rogozińska, Natalia, et al.
Publicado: (2019)

Efficiency of Immunotoxin Cytotoxicity Is Modulated by the Intracellular Itinerary
por: Tortorella, Lori L., et al.
Publicado: (2012)

Ricin A Chain Insertion into Endoplasmic Reticulum Membranes Is Triggered by a Temperature Increase to 37 °C
por: Mayerhofer, Peter U., et al.
Publicado: (2009)

Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain
Publicado: (1984)

Introduction of B-chain-inactivated ricin into mouse macrophages and rat Kupffer cells via their membrane Fc receptors
Publicado: (1976)

Monolith affinity chromatography for the rapid quantification of a single‐chain variable fragment immunotoxin
por: Satzer, Peter, et al.
Publicado: (2018)

Directing ricin-based immunotoxins with targeting affibodies and KDEL signal peptide to cancer cells effectively induces apoptosis and tumor suppression
por: Park, Seong Guk, et al.
Publicado: (2022)

The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain
por: Pietroni, Paola, et al.
Publicado: (2013)

Inhibition of the Unfolded Protein Response by Ricin A-Chain Enhances Its Cytotoxicity in Mammalian Cells
por: Wang, Chao-Ting, et al.
Publicado: (2011)

Selective cytotoxicity of a novel immunotoxin based on pulchellin A chain for cells expressing HIV envelope
por: Sadraeian, Mohammad, et al.
Publicado: (2017)

Peptide Mimics of the Ribosomal P Stalk Inhibit the Activity of Ricin A Chain by Preventing Ribosome Binding
por: Li, Xiao-Ping, et al.
Publicado: (2018)

Folding-competent and Folding-defective Forms of Ricin A Chain Have Different Fates after Retrotranslocation from the Endoplasmic Reticulum
por: Li, Shuyu, et al.
Publicado: (2010)

A Retrograde Trafficking Inhibitor of Ricin and Shiga-Like Toxins Inhibits Infection of Cells by Human and Monkey Polyomaviruses
por: Nelson, Christian D. S., et al.
Publicado: (2013)

Routing of internalized ricin and ricin conjugates to the Golgi complex
Publicado: (1986)

Countering immunotoxin immunogenicity
por: Flavell, David J
Publicado: (2016)

ISOLATION OF CRYSTALLINE RICIN
por: Kunitz, M., et al.
Publicado: (1948)

Pterin-based small molecule inhibitor capable of binding to the secondary pocket in the active site of ricin-toxin A chain
por: Saito, Ryota, et al.
Publicado: (2022)

Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor
por: Goto, Masaru, et al.
Publicado: (2023)

Immunotoxins Targeting B cell Malignancy—Progress and Problems With Immunogenicity
por: Vallera, Daniel A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mnbdsk5javdduqnlu7j8kr20hj