DNA aneuploidy and low S-phase fraction as favourable prognostic signs in metastatic melanoma.

The prognostic value of cellular DNA content in melanoma metastases was investigated by flow cytometric analysis of fresh or paraffin-embedded tumour blocks from 95 consecutive patients referred to the Helsinki University Central Hospital Melanoma Team. Thirty-three per cent of the tumours were DNA...

Descripción completa

Detalles Bibliográficos
Autores principales: Muhonen, T., Pyrhönen, S., Laasonen, A., Asko-Seljavaara, S., Franssila, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977691/
https://www.ncbi.nlm.nih.gov/pubmed/1911224
_version_ 1782135316680802304
author Muhonen, T.
Pyrhönen, S.
Laasonen, A.
Asko-Seljavaara, S.
Franssila, K.
author_facet Muhonen, T.
Pyrhönen, S.
Laasonen, A.
Asko-Seljavaara, S.
Franssila, K.
author_sort Muhonen, T.
collection PubMed
description The prognostic value of cellular DNA content in melanoma metastases was investigated by flow cytometric analysis of fresh or paraffin-embedded tumour blocks from 95 consecutive patients referred to the Helsinki University Central Hospital Melanoma Team. Thirty-three per cent of the tumours were DNA diploid and 67% DNA aneuploid. S-phase fractions were lower in DNA diploid than in DNA aneuploid tumours (10.7% and 17.6%). Tumour ploidy and S-phase fraction were shown by multivariate Cox model analysis to be independent prognostic variables and major determinants of survival after first recurrence. Surprisingly, patients with DNA aneuploid tumours and with tumours with low SPF survived significantly longer than those with DNA diploid or high SPF tumours. This exceptional finding of favourable prognosis for DNA aneuploid tumours was more prominent among patients receiving intensive systemic therapy and among patients with stage IV disease, probably indicating a tendency for DNA aneuploid tumours to have higher sensitivity to systemic therapy.
format Text
id pubmed-1977691
institution National Center for Biotechnology Information
language English
publishDate 1991
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19776912009-09-10 DNA aneuploidy and low S-phase fraction as favourable prognostic signs in metastatic melanoma. Muhonen, T. Pyrhönen, S. Laasonen, A. Asko-Seljavaara, S. Franssila, K. Br J Cancer Research Article The prognostic value of cellular DNA content in melanoma metastases was investigated by flow cytometric analysis of fresh or paraffin-embedded tumour blocks from 95 consecutive patients referred to the Helsinki University Central Hospital Melanoma Team. Thirty-three per cent of the tumours were DNA diploid and 67% DNA aneuploid. S-phase fractions were lower in DNA diploid than in DNA aneuploid tumours (10.7% and 17.6%). Tumour ploidy and S-phase fraction were shown by multivariate Cox model analysis to be independent prognostic variables and major determinants of survival after first recurrence. Surprisingly, patients with DNA aneuploid tumours and with tumours with low SPF survived significantly longer than those with DNA diploid or high SPF tumours. This exceptional finding of favourable prognosis for DNA aneuploid tumours was more prominent among patients receiving intensive systemic therapy and among patients with stage IV disease, probably indicating a tendency for DNA aneuploid tumours to have higher sensitivity to systemic therapy. Nature Publishing Group 1991-10 /pmc/articles/PMC1977691/ /pubmed/1911224 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Muhonen, T.
Pyrhönen, S.
Laasonen, A.
Asko-Seljavaara, S.
Franssila, K.
DNA aneuploidy and low S-phase fraction as favourable prognostic signs in metastatic melanoma.
title DNA aneuploidy and low S-phase fraction as favourable prognostic signs in metastatic melanoma.
title_full DNA aneuploidy and low S-phase fraction as favourable prognostic signs in metastatic melanoma.
title_fullStr DNA aneuploidy and low S-phase fraction as favourable prognostic signs in metastatic melanoma.
title_full_unstemmed DNA aneuploidy and low S-phase fraction as favourable prognostic signs in metastatic melanoma.
title_short DNA aneuploidy and low S-phase fraction as favourable prognostic signs in metastatic melanoma.
title_sort dna aneuploidy and low s-phase fraction as favourable prognostic signs in metastatic melanoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977691/
https://www.ncbi.nlm.nih.gov/pubmed/1911224
work_keys_str_mv AT muhonent dnaaneuploidyandlowsphasefractionasfavourableprognosticsignsinmetastaticmelanoma
AT pyrhonens dnaaneuploidyandlowsphasefractionasfavourableprognosticsignsinmetastaticmelanoma
AT laasonena dnaaneuploidyandlowsphasefractionasfavourableprognosticsignsinmetastaticmelanoma
AT askoseljavaaras dnaaneuploidyandlowsphasefractionasfavourableprognosticsignsinmetastaticmelanoma
AT franssilak dnaaneuploidyandlowsphasefractionasfavourableprognosticsignsinmetastaticmelanoma

Ejemplares similares