Neuron-specific enolase--a serum tumour marker in seminoma?

The clinical significance of neuron-specific enolase (NSE) as a tumour marker was evaluated in 54 patients with seminoma. Before orchiectomy NSE was elevated in six out of 21 patients with stage I seminoma and 11 out of 16 patients with metastases. After orchiectomy NSE normalised in all evaluated s...

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Autores principales: Fosså, S. D., Klepp, O., Paus, E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977726/
https://www.ncbi.nlm.nih.gov/pubmed/1739633
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author Fosså, S. D.
Klepp, O.
Paus, E.
author_facet Fosså, S. D.
Klepp, O.
Paus, E.
author_sort Fosså, S. D.
collection PubMed
description The clinical significance of neuron-specific enolase (NSE) as a tumour marker was evaluated in 54 patients with seminoma. Before orchiectomy NSE was elevated in six out of 21 patients with stage I seminoma and 11 out of 16 patients with metastases. After orchiectomy NSE normalised in all evaluated stage I cases, but was still elevated in six out of 12 patients with metastatic disease. NSE monitored the effect of cisplatin-based chemotherapy in patients with metastases. In some patients, increased serum NSE was found together with raised levels of human choriogonadotropin (HCG) and lactate dehydrogenase (LDH), while in others only NSE was elevated. No false positive NSE values were observed. NSE seems to be a clinically worthwhile serum tumour marker for monitoring seminoma patients, with a sensitivity and specificity of the same order as HCG.
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spelling pubmed-19777262009-09-10 Neuron-specific enolase--a serum tumour marker in seminoma? Fosså, S. D. Klepp, O. Paus, E. Br J Cancer Research Article The clinical significance of neuron-specific enolase (NSE) as a tumour marker was evaluated in 54 patients with seminoma. Before orchiectomy NSE was elevated in six out of 21 patients with stage I seminoma and 11 out of 16 patients with metastases. After orchiectomy NSE normalised in all evaluated stage I cases, but was still elevated in six out of 12 patients with metastatic disease. NSE monitored the effect of cisplatin-based chemotherapy in patients with metastases. In some patients, increased serum NSE was found together with raised levels of human choriogonadotropin (HCG) and lactate dehydrogenase (LDH), while in others only NSE was elevated. No false positive NSE values were observed. NSE seems to be a clinically worthwhile serum tumour marker for monitoring seminoma patients, with a sensitivity and specificity of the same order as HCG. Nature Publishing Group 1992-02 /pmc/articles/PMC1977726/ /pubmed/1739633 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Fosså, S. D.
Klepp, O.
Paus, E.
Neuron-specific enolase--a serum tumour marker in seminoma?
title Neuron-specific enolase--a serum tumour marker in seminoma?
title_full Neuron-specific enolase--a serum tumour marker in seminoma?
title_fullStr Neuron-specific enolase--a serum tumour marker in seminoma?
title_full_unstemmed Neuron-specific enolase--a serum tumour marker in seminoma?
title_short Neuron-specific enolase--a serum tumour marker in seminoma?
title_sort neuron-specific enolase--a serum tumour marker in seminoma?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977726/
https://www.ncbi.nlm.nih.gov/pubmed/1739633
work_keys_str_mv AT fossasd neuronspecificenolaseaserumtumourmarkerinseminoma
AT kleppo neuronspecificenolaseaserumtumourmarkerinseminoma
AT pause neuronspecificenolaseaserumtumourmarkerinseminoma

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